Hepatoma-Derived Growth Factor-Related Protein (HRP)-1 Gene in Spermatogenesis in Mice

Hepatoma-Derived Growth Factor-Related Protein (HRP)-1 Gene in Spermatogenesis in Mice Hepatoma-derived growth factor (HDGF)-related protein (HRP)-1, a member of the HDGF gene family, showed testis-specific expression in mice. HRP-1 expression in spermatogenesis was analyzed in the testis of normal and azoospermic mice by Northern blot and immunohistochemistry. HRP-1 gene message was not expressed in the ovary and its product was detected only in the nuclei of germ cells, not in somatic cells. The HRP-1 gene is expressed through pachytene spermatocyte to round spermatid. HRP-1 gene expression was not detected in the testis of cryptorchid mice or in some strains of mutant mice. These findings suggest that the testis-specific HRP-1 gene may play an important role in the phase around meiotic cell division. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biochemical and Biophysical Research Communications Elsevier

Hepatoma-Derived Growth Factor-Related Protein (HRP)-1 Gene in Spermatogenesis in Mice

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Publisher
Elsevier
Copyright
Copyright © 1999 Academic Press
ISSN
0006-291x
D.O.I.
10.1006/bbrc.1999.1115
Publisher site
See Article on Publisher Site

Abstract

Hepatoma-derived growth factor (HDGF)-related protein (HRP)-1, a member of the HDGF gene family, showed testis-specific expression in mice. HRP-1 expression in spermatogenesis was analyzed in the testis of normal and azoospermic mice by Northern blot and immunohistochemistry. HRP-1 gene message was not expressed in the ovary and its product was detected only in the nuclei of germ cells, not in somatic cells. The HRP-1 gene is expressed through pachytene spermatocyte to round spermatid. HRP-1 gene expression was not detected in the testis of cryptorchid mice or in some strains of mutant mice. These findings suggest that the testis-specific HRP-1 gene may play an important role in the phase around meiotic cell division.

Journal

Biochemical and Biophysical Research CommunicationsElsevier

Published: Aug 27, 1999

References

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