Harnessing the Response to Tissue Hypoxia

Harnessing the Response to Tissue Hypoxia In most cell types a family of transcriptional regulatory proteins termed hypoxia-inducible factors, of which HIF-1 is the most prevalent, mediates the physiologic response to hypoxia. Although much has been learned over the past decade since the discovery of the first HIF family member, the proximal signaling events linking a decline in oxygen concentration to the activation of HIF-dependent signaling are only now being clarified. Activation of HIF-1 in eukaryotes induces expression of many genes that assist in adapting the organism to an environment in which oxygen is limiting, such as of genes involved in new blood vessel formation, including isoforms of vascular endothelial growth factor and angiopoietins, among others. Targeted expression of constitutively active HIF transgenes to ischemic tissues may be beneficial as a form of therapeutic angiogenesis. (Trends in Cardiovasc Med 2002; 12:362–367). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Trends in Cardiovascular Medicine Elsevier

Harnessing the Response to Tissue Hypoxia

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Inc.
ISSN
1050-1738
D.O.I.
10.1016/S1050-1738(02)00186-X
Publisher site
See Article on Publisher Site

Abstract

In most cell types a family of transcriptional regulatory proteins termed hypoxia-inducible factors, of which HIF-1 is the most prevalent, mediates the physiologic response to hypoxia. Although much has been learned over the past decade since the discovery of the first HIF family member, the proximal signaling events linking a decline in oxygen concentration to the activation of HIF-dependent signaling are only now being clarified. Activation of HIF-1 in eukaryotes induces expression of many genes that assist in adapting the organism to an environment in which oxygen is limiting, such as of genes involved in new blood vessel formation, including isoforms of vascular endothelial growth factor and angiopoietins, among others. Targeted expression of constitutively active HIF transgenes to ischemic tissues may be beneficial as a form of therapeutic angiogenesis. (Trends in Cardiovasc Med 2002; 12:362–367).

Journal

Trends in Cardiovascular MedicineElsevier

Published: Nov 1, 2002

References

  • Signal transduction in hypoxic cells
    Kallio, P.J.; Okamoto, K.; O'Brien, S.
  • Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication
    Lederman, R.J.; Mendelsohn, F.O.; Anderson, R.D.
  • FIH-1
    Mahon, P.C.; Hirota, K.; Semenza, G.L.
  • Activation of the HIF pathway in cancer
    Maxwell, P.H.; Pugh, C.W.; Ratcliffe, P.J.
  • Activation of hypoxia-inducible factor-1
    Pugh, C.W.; O'Rourke, J.F.; Nagao, M.
  • Cardiotoxicity in signal transduction therapeutics
    Schneider, J.W.; Chang, A.Y.; Rocco, T.P.

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