Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control

Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but... •Gut expression of guanylin peptides is elevated in obese patients upon gastric bypass.•Guanylin and uroguanylin show no body weight or glucoregulatory effects in mice.•Uroguanylin has no effect on glucose-stimulated insulin secretion in rat pancreas.•Adenoviral gene delivery of uroguanylin is weight-neutral in diet-induced obese rats.•Guanylin peptides do not show promise as novel targets in diabetes and obesity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Peptides Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
0196-9781
D.O.I.
10.1016/j.peptides.2017.12.024
Publisher site
See Article on Publisher Site

Abstract

•Gut expression of guanylin peptides is elevated in obese patients upon gastric bypass.•Guanylin and uroguanylin show no body weight or glucoregulatory effects in mice.•Uroguanylin has no effect on glucose-stimulated insulin secretion in rat pancreas.•Adenoviral gene delivery of uroguanylin is weight-neutral in diet-induced obese rats.•Guanylin peptides do not show promise as novel targets in diabetes and obesity.

Journal

PeptidesElsevier

Published: Mar 1, 2018

References

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