Growth factors and antimicrobial factors of bovine colostrum

Growth factors and antimicrobial factors of bovine colostrum Colostrum is the first natural food produced by female mammals during the first 24–36h directly after giving birth. Chemically, colostrum is a very complex fluid rich in nutrients, antibodies and growth factors. In cows the antibodies provide passive immunity to the new born calf, whereas the growth factors especially stimulate the growth of the gut. The other antimicrobial components of colostrum include lactoferrin, lysozyme and lactoperoxidase. Bovine colostrum has also been used as a raw material for immunonoglubulin-rich commercial products (immune milk preparations). These products can be given orally to patients who are suffering infections of the gastrointestial tract or in order to prevent these infections. Usually, however, the cows have to be hyperimmunized against microorganisms, if specific antibodies are required. Several animal studies have shown that the growth factors in bovine colostrum, especially insulin-like growth factors, stimulate cell growth in the gut. Bovine colostrum is also known to contain insulin, transforming growth factor β and related growth factors, but their function in colostrum is not fully understood. Small amounts of these growth factors can also be detected in normal milk. Growth factors as well as antimicrobial factors of colostrum may be used as potential components in clinical nutrition in the future. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Dairy Journal Elsevier

Growth factors and antimicrobial factors of bovine colostrum

International Dairy Journal, Volume 7 (5) – May 1, 1997

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Ltd
ISSN
0958-6946
eISSN
1879-0143
DOI
10.1016/S0958-6946(97)00022-8
Publisher site
See Article on Publisher Site

Abstract

Colostrum is the first natural food produced by female mammals during the first 24–36h directly after giving birth. Chemically, colostrum is a very complex fluid rich in nutrients, antibodies and growth factors. In cows the antibodies provide passive immunity to the new born calf, whereas the growth factors especially stimulate the growth of the gut. The other antimicrobial components of colostrum include lactoferrin, lysozyme and lactoperoxidase. Bovine colostrum has also been used as a raw material for immunonoglubulin-rich commercial products (immune milk preparations). These products can be given orally to patients who are suffering infections of the gastrointestial tract or in order to prevent these infections. Usually, however, the cows have to be hyperimmunized against microorganisms, if specific antibodies are required. Several animal studies have shown that the growth factors in bovine colostrum, especially insulin-like growth factors, stimulate cell growth in the gut. Bovine colostrum is also known to contain insulin, transforming growth factor β and related growth factors, but their function in colostrum is not fully understood. Small amounts of these growth factors can also be detected in normal milk. Growth factors as well as antimicrobial factors of colostrum may be used as potential components in clinical nutrition in the future.

Journal

International Dairy JournalElsevier

Published: May 1, 1997

References

  • The relationship between the insulin content and inhibitory effects of bovine colostrum on protein breakdown in cultured cells
    Ballard, F.J.; Nield, M.K.; Francis, G.L.; Dahlenburg, G.W.; Wallace, J.C.
  • Plasma-derived protease inhibitors in bovine milk
    Christensen, S.; Wiegers, T.; Hermansen, J.; Sottrup-Jensen, L.
  • Growth factors in milk as mediators of infant development
    D⊙novan, S.M.; Odle, J.
  • Passive immunizations of suckling mice and infants with bovine colostrum containing antibodies to human rotavirus
    Ebina, T.; Ohta, M.; Kanamaru, Y.; Yamamoto-Osumi, Y.; Baba, K.
  • Actions of insulin-like growth factors
    Froesch, E.R.; Schmid, C.; Schwandr, J.; Zapf, J.
  • Insulin-like growth factor-1 stimulates amino acid uptake by the cultured human placental trophoblast
    Karl, P.I.
  • Human milk stimulates DNA synthesis and cellular proliferation in cultured fibroblasts
    Klagsbrun, M.
  • Bovine colostrum supports the serum-free proliferation of epithelial cells but not fibroblasts in long-term culture
    Klagsbrun, M.
  • Receptors for insulin like growth factors I and II in rat gastrointestinal epithelium
    Laburthe, M.; Rouyer-Fessarrd, C.; Gameltoff, S.
  • Lactoferrin: Molecular structure and biological function
    Lönnerdahl, B.; Iyer, S.
  • Transforming growth factor beta 1 selectively stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cell
    McIntyre, T.M.; Klinman, D.R.; Rothman, P.; Lugo, M.; Dasch, J.R.; Mond, J.J.; Snapper, C.M.
  • Bovine colostrum or milk as a serum substitute for the cultivation of a mouse hybridoma
    Ramirez, O.T.; Sureshkumar, G.K.; Mutharasan, R.
  • Prolonged administration of IGF peptides enhances growth of gastrointestinal tissues in normal rats
    Steeb, C.B.; Trahair, J.F.; Tomas, F.M.; Read, L.C.
  • The serum-free growth of cultured cells in bovine colostrum and in milk obtained later in the lactation period
    Steimer, K.S.; Packard, R.; Holden, D.; Klagsbrun, M.

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