Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein

Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by... This study investigated whether human vascular smooth muscle cell proliferation induced by native low-density lipoprotein (LDL) is affected by green tea catechins. Furthermore, the effects of native LDL on extracellular signal-regulated kinase (ERK) 1/2 activity were determined. Cell proliferation stimulated by native LDL was concentration-dependently inhibited by epigallocatechin, epigallocatechin-3-gallate, green tea polyphenon, and the nonspecific antioxidant N -acetylcysteine ( P <0.05). Combined treatment of green tea polyphenon and N -acetylcysteine markedly potentiated the effect of each drug on vascular smooth muscle cell proliferation. ERK1/2 activity was only partly inhibited by green tea catechins alone or in combination with N -acetylcysteine ( P <0.05). These data suggest that green tea constituents inhibit proliferation of human vascular smooth muscle cells exposed to high levels of native LDL. Green tea constituents and antioxidants may exert vascular protection by inhibiting human vascular smooth muscle cell growth associated with hypercholesterolemia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(01)01535-7
Publisher site
See Article on Publisher Site

Abstract

This study investigated whether human vascular smooth muscle cell proliferation induced by native low-density lipoprotein (LDL) is affected by green tea catechins. Furthermore, the effects of native LDL on extracellular signal-regulated kinase (ERK) 1/2 activity were determined. Cell proliferation stimulated by native LDL was concentration-dependently inhibited by epigallocatechin, epigallocatechin-3-gallate, green tea polyphenon, and the nonspecific antioxidant N -acetylcysteine ( P <0.05). Combined treatment of green tea polyphenon and N -acetylcysteine markedly potentiated the effect of each drug on vascular smooth muscle cell proliferation. ERK1/2 activity was only partly inhibited by green tea catechins alone or in combination with N -acetylcysteine ( P <0.05). These data suggest that green tea constituents inhibit proliferation of human vascular smooth muscle cells exposed to high levels of native LDL. Green tea constituents and antioxidants may exert vascular protection by inhibiting human vascular smooth muscle cell growth associated with hypercholesterolemia.

Journal

European Journal of PharmacologyElsevier

Published: Jan 2, 2002

References

  • Therapeutic interventions for hypercholesterolemia
    Gotto, A.M.
  • Low-density lipoprotein-induced formation of nitric oxide by cultured vascular smooth muscle cells of the rat
    Locher, R.; Suter, P.M.; Weisser, B.; Vetter, W.
  • A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation
    Skalli, O.

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