Graded photochemical spinal cord injury results in chronic hyperalgesia and depression-like behaviour but no anxiety exacerbation in female BALB/c mice

Graded photochemical spinal cord injury results in chronic hyperalgesia and depression-like... •Photochemical SCI associates with long-lasting chronic thermal hyperalgesia.•Chronic central hyperalgesia results in despair behaviour in BALB/c mice.•Chronic central hyperalgesia does not exacerbate BALB/c anxiety-like behaviour.•Photochemical SCI causes graded CGRP- and GFAP-immunoreactivity up to chronic phase.•BALB/c strain is suitable to study chronic hyperalgesia and mood disorders comorbidity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Graded photochemical spinal cord injury results in chronic hyperalgesia and depression-like behaviour but no anxiety exacerbation in female BALB/c mice

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0304-3940
D.O.I.
10.1016/j.neulet.2017.11.007
Publisher site
See Article on Publisher Site

Abstract

•Photochemical SCI associates with long-lasting chronic thermal hyperalgesia.•Chronic central hyperalgesia results in despair behaviour in BALB/c mice.•Chronic central hyperalgesia does not exacerbate BALB/c anxiety-like behaviour.•Photochemical SCI causes graded CGRP- and GFAP-immunoreactivity up to chronic phase.•BALB/c strain is suitable to study chronic hyperalgesia and mood disorders comorbidity.

Journal

Neuroscience LettersElsevier

Published: Jan 18, 2018

References

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