•Oral scrapie challenge of control goats resulted in clinical signs of scrapie in less than 2 years on average.•Goats with one copy of S146 or K222 were free of clinical scrapie for 2734 and 2450days post-inoculation, respectively.•The S146 group survival time free of clinical scrapie is the longest reported of any scrapie-challenged goat genotype.•The K222 group survival time free of clinical scrapie is the longest reported for scrapie-challenged K222-bearing goats.•Goats with S146 or K222 alleles may delay clinical scrapie beyond the productive lifetimes of many commercial goats.
The Veterinary Journal – Elsevier
Published: Mar 1, 2018
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