Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years

Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth... •Oral scrapie challenge of control goats resulted in clinical signs of scrapie in less than 2 years on average.•Goats with one copy of S146 or K222 were free of clinical scrapie for 2734 and 2450days post-inoculation, respectively.•The S146 group survival time free of clinical scrapie is the longest reported of any scrapie-challenged goat genotype.•The K222 group survival time free of clinical scrapie is the longest reported for scrapie-challenged K222-bearing goats.•Goats with S146 or K222 alleles may delay clinical scrapie beyond the productive lifetimes of many commercial goats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Veterinary Journal Elsevier

Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond 6 years

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
1090-0233
D.O.I.
10.1016/j.tvjl.2017.12.019
Publisher site
See Article on Publisher Site

Abstract

•Oral scrapie challenge of control goats resulted in clinical signs of scrapie in less than 2 years on average.•Goats with one copy of S146 or K222 were free of clinical scrapie for 2734 and 2450days post-inoculation, respectively.•The S146 group survival time free of clinical scrapie is the longest reported of any scrapie-challenged goat genotype.•The K222 group survival time free of clinical scrapie is the longest reported for scrapie-challenged K222-bearing goats.•Goats with S146 or K222 alleles may delay clinical scrapie beyond the productive lifetimes of many commercial goats.

Journal

The Veterinary JournalElsevier

Published: Mar 1, 2018

References

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