Glycosylated α-lactalbumin-based nanocomplex for curcumin: Physicochemical stability and DPPH-scavenging activity

Glycosylated α-lactalbumin-based nanocomplex for curcumin: Physicochemical stability and... Low stability at high salt concentrations, iso-electric point, and high temperature restricted the application of proteins as stabilizers in nutraceutical encapsulation. Protein-polysaccharide conjugates made with Maillard reactions may be better alternatives. In this study, the characteristics of curcumin nanocomplexes prepared with both α-lactalbumin (ALA) and ALA-dextran conjugates as well as the effects of encapsulations on the physicochemical stability and the antioxidant activity of curcumin were evaluated. Curcumin aqueous dispersibility was boosted with nanoencapsulation. The sizes of nanoparticles coated with ALA and ALA-dextran conjugates were 63.5 ± 1.2 and 68.1 ± 2.9, respectively. Encapsulation efficiency (EE) and loading amount (LA) was not influenced with glycosylation. Stability under environmental stresses has significantly improved with ALA-dextran conjugates, compared to ALA. The oxidative stability of curcumin was also remarkably increased, especially with ALA-dextran conjugates at 95 °C. Curcumin coated in ALA and ALA-dextran conjugates had higher DPPH-scavenging activity, compared to free curcumin. ALA-dextran conjugates based nanocarrier may be an excellent delivery system for curcumin to expand the application in a wide range of food products. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Food Hydrocolloids Elsevier

Glycosylated α-lactalbumin-based nanocomplex for curcumin: Physicochemical stability and DPPH-scavenging activity

Loading next page...
 
/lp/elsevier/glycosylated-lactalbumin-based-nanocomplex-for-curcumin-qawSbXrvip
Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0268-005X
eISSN
1873-7137
D.O.I.
10.1016/j.foodhyd.2016.05.036
Publisher site
See Article on Publisher Site

Abstract

Low stability at high salt concentrations, iso-electric point, and high temperature restricted the application of proteins as stabilizers in nutraceutical encapsulation. Protein-polysaccharide conjugates made with Maillard reactions may be better alternatives. In this study, the characteristics of curcumin nanocomplexes prepared with both α-lactalbumin (ALA) and ALA-dextran conjugates as well as the effects of encapsulations on the physicochemical stability and the antioxidant activity of curcumin were evaluated. Curcumin aqueous dispersibility was boosted with nanoencapsulation. The sizes of nanoparticles coated with ALA and ALA-dextran conjugates were 63.5 ± 1.2 and 68.1 ± 2.9, respectively. Encapsulation efficiency (EE) and loading amount (LA) was not influenced with glycosylation. Stability under environmental stresses has significantly improved with ALA-dextran conjugates, compared to ALA. The oxidative stability of curcumin was also remarkably increased, especially with ALA-dextran conjugates at 95 °C. Curcumin coated in ALA and ALA-dextran conjugates had higher DPPH-scavenging activity, compared to free curcumin. ALA-dextran conjugates based nanocarrier may be an excellent delivery system for curcumin to expand the application in a wide range of food products.

Journal

Food HydrocolloidsElsevier

Published: Dec 1, 2016

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve Freelancer

DeepDyve Pro

Price
FREE
$49/month

$360/year
Save searches from
Google Scholar,
PubMed
Create lists to
organize your research
Export lists, citations
Read DeepDyve articles
Abstract access only
Unlimited access to over
18 million full-text articles
Print
20 pages/month
PDF Discount
20% off