Glufosinate ammonium induces convulsion through N -methyl- d -aspartate receptors in mice

Glufosinate ammonium induces convulsion through N -methyl- d -aspartate receptors in mice Glufosinate ammonium, a broad-spectrum herbicide, causes convulsion in rodents and humans. Because of the structural similarities between glufosinate and glutamate, the convulsion induced by glufosinate ammonium may be ascribed to glutamate receptor activation. Three N -methyl- d -asparate (NMDA) receptor antagonists, dizocilpine, LY235959, and Compound 40, and an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist, NBQX, were coadministrated with glufosinate ammonium (80 mg/kg, intraperitoneally) in mice. Statistical analyses showed that the NMDA receptor antagonists markedly inhibited the convulsions, while the AMPA/kainate receptor antagonist had no effect on the convulsion. These results suggest that the convulsion caused by glufosinate ammonium is mediated through NMDA receptors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Glufosinate ammonium induces convulsion through N -methyl- d -aspartate receptors in mice

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Ireland Ltd
ISSN
0304-3940
DOI
10.1016/S0304-3940(01)01765-7
Publisher site
See Article on Publisher Site

Abstract

Glufosinate ammonium, a broad-spectrum herbicide, causes convulsion in rodents and humans. Because of the structural similarities between glufosinate and glutamate, the convulsion induced by glufosinate ammonium may be ascribed to glutamate receptor activation. Three N -methyl- d -asparate (NMDA) receptor antagonists, dizocilpine, LY235959, and Compound 40, and an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate receptor antagonist, NBQX, were coadministrated with glufosinate ammonium (80 mg/kg, intraperitoneally) in mice. Statistical analyses showed that the NMDA receptor antagonists markedly inhibited the convulsions, while the AMPA/kainate receptor antagonist had no effect on the convulsion. These results suggest that the convulsion caused by glufosinate ammonium is mediated through NMDA receptors.

Journal

Neuroscience LettersElsevier

Published: May 18, 2001

References

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