Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines ( Equus caballus )

Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines ( Equus... To investigate the enteroinsular axis (EIA) in equines oral (oGTT) and intravenous (i.v.GTT) glucose tolerance tests (5.6 and 1 mmol glucose/kg BW, respectively) were performed with healthy, normal weight large horses and Shetland ponies. Plasma was analysed for concentrations of glucose, glucose-dependent insulinotropic polypeptide (GIP) and insulin. In all equines plasma GIP concentrations only increased significantly when glucose was administered orally. The insulin glucose ratio (IGR) was significantly higher during the oGTT than during the i.v.GTT in both races. Basal plasma glucose levels were significantly higher in large horses than in ponies in both experiments. During the oGTT maximum glucose values were significantly higher in ponies. Ponies tended to a higher insulin secretion but the IGRs were identical in both races after oral and intravenous glucose administration. One clinically inconspicuous pony showed hyperinsulinaemia and, in case of the oGTT, insulin resistance, glucose intolerance, and GIP hypersecretion. The results of this study indicate the existence of an EIA in equines due to the higher IGRs during the oGTT. Furthermore, the similarity of plasma GIP levels and IGRs in ponies and large horses suggest a comparable activity of the EIA in both races. Regarding the elevated plasma GIP concentrations of the insulin resistant pony the EIA appears to participate in equine hyperinsulinaemia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology Elsevier

Glucose-dependent insulinotropic polypeptide (GIP) and the enteroinsular axis in equines ( Equus caballus )

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Inc.
ISSN
1095-6433
eISSN
1531-4332
D.O.I.
10.1016/S1095-6433(01)00295-1
Publisher site
See Article on Publisher Site

Abstract

To investigate the enteroinsular axis (EIA) in equines oral (oGTT) and intravenous (i.v.GTT) glucose tolerance tests (5.6 and 1 mmol glucose/kg BW, respectively) were performed with healthy, normal weight large horses and Shetland ponies. Plasma was analysed for concentrations of glucose, glucose-dependent insulinotropic polypeptide (GIP) and insulin. In all equines plasma GIP concentrations only increased significantly when glucose was administered orally. The insulin glucose ratio (IGR) was significantly higher during the oGTT than during the i.v.GTT in both races. Basal plasma glucose levels were significantly higher in large horses than in ponies in both experiments. During the oGTT maximum glucose values were significantly higher in ponies. Ponies tended to a higher insulin secretion but the IGRs were identical in both races after oral and intravenous glucose administration. One clinically inconspicuous pony showed hyperinsulinaemia and, in case of the oGTT, insulin resistance, glucose intolerance, and GIP hypersecretion. The results of this study indicate the existence of an EIA in equines due to the higher IGRs during the oGTT. Furthermore, the similarity of plasma GIP levels and IGRs in ponies and large horses suggest a comparable activity of the EIA in both races. Regarding the elevated plasma GIP concentrations of the insulin resistant pony the EIA appears to participate in equine hyperinsulinaemia.

Journal

Comparative Biochemistry and Physiology - Part A: Molecular & Integrative PhysiologyElsevier

Published: Jun 1, 2001

References

  • Comparative aspects of glucose tolerance in camels, sheep and ponies
    Elmahdi, B; Sallmann, H.-P; Fuhrmann, H; von Engelhardt, W; Kaske, M
  • Insulin and glucose response following oral glucose administration in well-conditioned ponies
    Freestone, J.F; Shoemaker, K; Bessin, R; Wolfsheimer, K.J
  • Changes in circulating gut hormones in the horse during long distance exercises
    Hall, G.M; Adrian, T.E; Bloom, S.C; Lucke, J.N
  • Release of gastric inhibitory polypeptide from cultured canine endocrine cells
    Kieffer, T.J; Buchan, A.M; Barker, H; Brown, J.C; Pederson, R.A
  • Small intestinal malabsorption in the horse: an assessment of the specificity of the oral glucose tolerance test
    Mair, T.S; Hillyer, M.H; Taylor, F.G.R; Pearson, G.R
  • The oral glucose tolerance test in the horse
    Roberts, M.C; Hill, F.W.G
  • Regulation of glucose-dependent insulinotropic peptide gene expression by a glucose meal
    Tseng, C.C; Jarboe, L.A; Wolfe, M.M

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