<h5>Glucocorticoids and the risk of laminitis in adult horses</h5> Glucocorticoids (GC) are steroid hormones derived from the adrenal cortices. They are essential for health  . Glucocorticoids also comprise an important group of commonly prescribed medications that provide the veterinarian with a diverse array of pharmacologic effects. They are used routinely for the management of many equine medical conditions including inflammatory airway disease, dermatitis, purpura hemorrhagica, central nervous system inflammation and trauma, hepatitis, immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, neoplasia, shock, and ophthalmic inflammation. Unfortunately, however, the systemic use of GCs in adult horses appears to be associated with a significant risk of laminitis [2–5] . In the first part of this article, we will address the association of GC with the pathogenesis of equine laminitis. In the second part, we will introduce the role of local tissue enzymes, specifically 11β-hydroxysteroid dehydrogenases, in the regulation of GC action at the cellular level.</P><h5>Systemic effects of glucocorticoids</h5> Glucocorticoid receptors (GR) are present primarily in the cytoplasm of virtually all of the cells of the horse's body  . Interaction of a GC with the GR leads to formation of an activated receptor complex, which exerts its transcriptional effects in the nucleus
Veterinary Clinics of North America: Equine Practice – Elsevier
Published: Aug 1, 2002
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