Glucocorticoids and laminitis in the horse

Glucocorticoids and laminitis in the horse <h5>Glucocorticoids and the risk of laminitis in adult horses</h5> Glucocorticoids (GC) are steroid hormones derived from the adrenal cortices. They are essential for health [1] . Glucocorticoids also comprise an important group of commonly prescribed medications that provide the veterinarian with a diverse array of pharmacologic effects. They are used routinely for the management of many equine medical conditions including inflammatory airway disease, dermatitis, purpura hemorrhagica, central nervous system inflammation and trauma, hepatitis, immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, neoplasia, shock, and ophthalmic inflammation. Unfortunately, however, the systemic use of GCs in adult horses appears to be associated with a significant risk of laminitis [2–5] . In the first part of this article, we will address the association of GC with the pathogenesis of equine laminitis. In the second part, we will introduce the role of local tissue enzymes, specifically 11β-hydroxysteroid dehydrogenases, in the regulation of GC action at the cellular level.</P><h5>Systemic effects of glucocorticoids</h5> Glucocorticoid receptors (GR) are present primarily in the cytoplasm of virtually all of the cells of the horse's body [1] . Interaction of a GC with the GR leads to formation of an activated receptor complex, which exerts its transcriptional effects in the nucleus http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Veterinary Clinics of North America: Equine Practice Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science (USA)
ISSN
0749-0739
eISSN
1558-4224
D.O.I.
10.1016/S0749-0739(02)00015-9
Publisher site
See Article on Publisher Site

Abstract

<h5>Glucocorticoids and the risk of laminitis in adult horses</h5> Glucocorticoids (GC) are steroid hormones derived from the adrenal cortices. They are essential for health [1] . Glucocorticoids also comprise an important group of commonly prescribed medications that provide the veterinarian with a diverse array of pharmacologic effects. They are used routinely for the management of many equine medical conditions including inflammatory airway disease, dermatitis, purpura hemorrhagica, central nervous system inflammation and trauma, hepatitis, immune-mediated hemolytic anemia, immune-mediated thrombocytopenia, neoplasia, shock, and ophthalmic inflammation. Unfortunately, however, the systemic use of GCs in adult horses appears to be associated with a significant risk of laminitis [2–5] . In the first part of this article, we will address the association of GC with the pathogenesis of equine laminitis. In the second part, we will introduce the role of local tissue enzymes, specifically 11β-hydroxysteroid dehydrogenases, in the regulation of GC action at the cellular level.</P><h5>Systemic effects of glucocorticoids</h5> Glucocorticoid receptors (GR) are present primarily in the cytoplasm of virtually all of the cells of the horse's body [1] . Interaction of a GC with the GR leads to formation of an activated receptor complex, which exerts its transcriptional effects in the nucleus

Journal

Veterinary Clinics of North America: Equine PracticeElsevier

Published: Aug 1, 2002

References

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    Brem, A.S.; Bina, R.B.; Mehta, S.
  • Expression of endothelin in equine laminitis
    Katwa, L.C.; Johnson, P.J.; Ganjam, V.K.
  • In vitro evidence for a bacterial pathogenesis of equine laminitis
    Mungall, B.A.; Kyaw-Tanner, M.; Pollitt, C.C.
  • Zymographic analysis of equine laminitis
    Mungall, B.A.; Pollitt, C.C.
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    Hood, D.M.; Grosenbaugh, D.A.; Mostafa, M.B.
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    Bitar, M.S.
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    Groves, R.W.; MacDonald, L.M.; MacDonald, D.M.
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    Pollitt, C.C.
  • Decreased glucose metabolism causes separation of hoof lamellae in vitro: a trigger for laminitis?
    Pass, M.A.; Pollitt, S.; Pollitt, C.C.
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    Meddings, J.B.; Swain, M.G.
  • Glucocorticoid induced osteoporosis
    Gennari, C.

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