Global gene expression changes in BV2 microglial cell line during rabies virus infection

Global gene expression changes in BV2 microglial cell line during rabies virus infection 1 Introduction</h5> The rabies virus (RABV), of the family Rhabdoviridae , is a highly neurotropic virus that usually causes a fatal infection in the central nervous systems (CNS) of all warm-blooded animals ( Bourhy and Sureau, 1990 ). Rabies virus is the causative agent of rabies, a zoonotic disease, which remains an important public health issue in that it causes 55,000 human deaths annually worldwide ( WHO, 2005 ). The main feature of RABV is neuroinvasiveness, which refers to its unique ability to invade the CNS from peripheral sites and is major facet of its pathogenicity.</P>Microglia, bone marrow-derived, macrophage-like cells exert a central role in immune surveillance and host defense against infectious agents in the CNS ( Rock et al., 2004 ). Microglia are activated early in response to infection or injury and are major players in both innate and immune-mediated CNS inflammatory responses ( Olson et al., 2001 ). Microglia act as scavengers (phagocytes) and antigen-presenting cells in the CNS, control the proliferation of astrocytes, and produce soluble factors associated with an immunologic response. Under normal conditions, microglial cells remain in a resting quiescent state lacking many of the effector functions whereas, in response to brain infection, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Infection, Genetics and Evolution Elsevier

Global gene expression changes in BV2 microglial cell line during rabies virus infection

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Publisher
Elsevier
Copyright
Copyright © 2013 Elsevier B.V.
ISSN
1567-1348
D.O.I.
10.1016/j.meegid.2013.09.016
Publisher site
See Article on Publisher Site

Abstract

1 Introduction</h5> The rabies virus (RABV), of the family Rhabdoviridae , is a highly neurotropic virus that usually causes a fatal infection in the central nervous systems (CNS) of all warm-blooded animals ( Bourhy and Sureau, 1990 ). Rabies virus is the causative agent of rabies, a zoonotic disease, which remains an important public health issue in that it causes 55,000 human deaths annually worldwide ( WHO, 2005 ). The main feature of RABV is neuroinvasiveness, which refers to its unique ability to invade the CNS from peripheral sites and is major facet of its pathogenicity.</P>Microglia, bone marrow-derived, macrophage-like cells exert a central role in immune surveillance and host defense against infectious agents in the CNS ( Rock et al., 2004 ). Microglia are activated early in response to infection or injury and are major players in both innate and immune-mediated CNS inflammatory responses ( Olson et al., 2001 ). Microglia act as scavengers (phagocytes) and antigen-presenting cells in the CNS, control the proliferation of astrocytes, and produce soluble factors associated with an immunologic response. Under normal conditions, microglial cells remain in a resting quiescent state lacking many of the effector functions whereas, in response to brain infection,

Journal

Infection, Genetics and EvolutionElsevier

Published: Dec 1, 2013

References

  • Chemokine profiling of Japanese encephalitis virus-infected mouse neuroblastoma cells by microarray and real-time RT-PCR: implication in neuropathogenesis
    Gupta, N.; Santhosh, S.R.; Babu, J.P.; Parida, M.M.; Rao, P.V.
  • Microglia as a source and target of cytokines
    Hanisch, U.K.
  • Variance stabilization applied to microarray data calibration and to the quantification of differential expression
    Huber, W.; von Heydebreck, A.; Sultmann, H.; Poustka, A.; Vingron, M.
  • Rabies viruses infect primary cultures of murine, feline, and human microglia and astrocytes
    Ray, N.B.; Power, C.; Lynch, W.P.; Ewalt, L.C.; Lodmell, D.L.
  • Linear models and empirical bayes methods for assessing differential expression in microarray experiments
    Smyth, G.K.
  • Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1
    Terenzi, F.; Saikia, P.; Sen, G.C.

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