Genomewide comparative phylogenetic and molecular evolutionary analysis of tubby-like protein family in Arabidopsis , rice, and poplar

Genomewide comparative phylogenetic and molecular evolutionary analysis of tubby-like protein... Tubby-like proteins, which are characterized by a highly conserved tubby domain, play an important role in the maintenance and function of neuronal cells during postdifferentiation and development in mammals. In additional to the tubby domain, most tubby-like proteins in plants also possess an F-box domain. Plants also appear to harbor a large number of TLP genes. To gain insight into how TLP genes evolved in plants, we conducted a comparative phylogenetic and molecular evolutionary analysis of the tubby-like protein gene family in Arabidopsis , rice, and poplar. Genomewide screening identified 11 TLP genes in Arabidopsis , 14 in rice, and 11 in poplar. Phylogenetic trees, domain organizations, and intron/exon structures classified this family into three subfamilies and indicated that species-specific expansion contributed to the evolution of this family in plants. We determined that in rice and poplar, the tubby-like protein family had expanded mainly through segmental duplication events. Tissue-specific expression analysis indicated that functional diversification of the duplicated TLP genes was a major feature of long-term evolution. Our results also demonstrated that the tubby and F-box domains had co-evolved during the evolution of proteins containing both domains. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genomics Elsevier

Genomewide comparative phylogenetic and molecular evolutionary analysis of tubby-like protein family in Arabidopsis , rice, and poplar

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Publisher
Elsevier
Copyright
Copyright © 2008 Elsevier Inc.
ISSN
0888-7543
eISSN
1089-8646
D.O.I.
10.1016/j.ygeno.2008.06.001
Publisher site
See Article on Publisher Site

Abstract

Tubby-like proteins, which are characterized by a highly conserved tubby domain, play an important role in the maintenance and function of neuronal cells during postdifferentiation and development in mammals. In additional to the tubby domain, most tubby-like proteins in plants also possess an F-box domain. Plants also appear to harbor a large number of TLP genes. To gain insight into how TLP genes evolved in plants, we conducted a comparative phylogenetic and molecular evolutionary analysis of the tubby-like protein gene family in Arabidopsis , rice, and poplar. Genomewide screening identified 11 TLP genes in Arabidopsis , 14 in rice, and 11 in poplar. Phylogenetic trees, domain organizations, and intron/exon structures classified this family into three subfamilies and indicated that species-specific expansion contributed to the evolution of this family in plants. We determined that in rice and poplar, the tubby-like protein family had expanded mainly through segmental duplication events. Tissue-specific expression analysis indicated that functional diversification of the duplicated TLP genes was a major feature of long-term evolution. Our results also demonstrated that the tubby and F-box domains had co-evolved during the evolution of proteins containing both domains.

Journal

GenomicsElsevier

Published: Oct 1, 2008

References

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