Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism

Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and... •TNFAIP8L2 was preferentially expressed in human myeloid cell types.•Tnfaip8l2 expression drastically decreased after lipopolysaccharide treatment in macrophages.•Tnfaip8l2 deficiency led to heightened gene expression enriched for leukocyte activation and lipid biosynthesis pathways.•Tnfaip8l2 negatively regulated mitochondrial respiration in response to lipopolysaccharide.•Hyperlipidemia condition upregulated Tnfaip8l2 gene expression in the adipose tissue. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Genome-wide analysis reveals TNFAIP8L2 as an immune checkpoint regulator of inflammation and metabolism

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.05.007
Publisher site
See Article on Publisher Site

Abstract

•TNFAIP8L2 was preferentially expressed in human myeloid cell types.•Tnfaip8l2 expression drastically decreased after lipopolysaccharide treatment in macrophages.•Tnfaip8l2 deficiency led to heightened gene expression enriched for leukocyte activation and lipid biosynthesis pathways.•Tnfaip8l2 negatively regulated mitochondrial respiration in response to lipopolysaccharide.•Hyperlipidemia condition upregulated Tnfaip8l2 gene expression in the adipose tissue.

Journal

Molecular ImmunologyElsevier

Published: Jul 1, 2018

References

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