Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 β in neonatal rats

Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting... •Genipin decreased the expression of glycogen synthase kinase (GSK)-3 β in lung tissues of hyperoxia-exposed rat pups.•Genipin inhibited the reduction of survival rate in hyperoxia-exposed rat pups.•Genipin attenuated lung injury and pulmonary hypertension in hyperoxia-exposed rat pups.•Genipin attenuated inflammation, oxidative stress, and fibrosis in hyperoxia-exposed rat pups.•Inhibition of GSK-3 β was involved in the protective effect of genipin. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nutrition Elsevier

Genipin attenuates hyperoxia-induced lung injury and pulmonary hypertension via targeting glycogen synthase kinase-3 β in neonatal rats

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Publisher
Elsevier
Copyright
Copyright © 2019 Elsevier Inc.
ISSN
0899-9007
D.O.I.
10.1016/j.nut.2018.05.017
Publisher site
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Abstract

•Genipin decreased the expression of glycogen synthase kinase (GSK)-3 β in lung tissues of hyperoxia-exposed rat pups.•Genipin inhibited the reduction of survival rate in hyperoxia-exposed rat pups.•Genipin attenuated lung injury and pulmonary hypertension in hyperoxia-exposed rat pups.•Genipin attenuated inflammation, oxidative stress, and fibrosis in hyperoxia-exposed rat pups.•Inhibition of GSK-3 β was involved in the protective effect of genipin.

Journal

NutritionElsevier

Published: Jan 1, 2019

References

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