International Journal of Biochemistry and Cell Biology 114 (2019) 105569 Contents lists available at ScienceDirect International Journal of Biochemistry and Cell Biology journal homepage: www.elsevier.com/locate/biocel Genetically targeted ﬂuorescent probes reveal dynamic calcium responses to adrenergic signaling in multiple cardiomyocyte compartments a a b a a Ivan Luptak , Robert Morgan , Tomas Baka , Dominique Croteau , Daniel Moverman , a c d a Hannah Sarnak , Michael Kirber , Markus M. Bachschmid , Wilson S. Colucci , a, David R. Pimentel Myocardial Biology Unit, Boston University School of Medicine, Boston, MA, United States Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia Cellular Imaging Core, Boston University School of Medicine, Boston, MA, United States Vascular Biology Unit, Boston University School of Medicine, Boston, MA, United States ARTIC L E I NF O ABSTRAC T 2+ Keywords: Calcium (Ca ), an important second messenger, regulates many cellular activities and varies spatiotemporally 2+ 2+ FRET imaging within the cell. Conventional methods to monitor Ca changes, such as synthetic Ca indicators, are not 2+ Calcium signaling targetable, while genetically encoded Ca indicators (GECI) can be precisely directed to cellular compartments. Cellular compartments 2+ GECIs are chimeric proteins composed of calmodulin
The International Journal of Biochemistry & Cell Biology – Elsevier
Published: Sep 1, 2019
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