1 Introduction</h5> Anthrax, a disease caused by Bacillus anthracis has gained prominence in the recent times due its potential implication as bio-warfare agent. Apart from the bioterrorist attacks, natural outbreaks continue to occur in many parts of the world especially in Central Asia, South America and Africa. The disease in nature affects animals but humans also contract the disease from animals or animal products. Recently, incidences of anthrax in wildlife from various national parks have also come in to light ( Fasanella et al., 2010; Hudson et al., 2008 ). The situation demands a pragmatic vaccination approach suitable for both human and veterinary purposes under natural circumstances or during iniquitous bioterror events.</P>The present human and veterinary anthrax vaccines rely on rather old-fashioned methods. The veterinary anthrax vaccine developed in 1930's by Sterne is essentially an attenuated, non-encapsulated, toxigenic strain of B. anthracis , while the licensed human vaccine predominantly contains ‘protective antigen’, the main immunogenic component of the tripartite anthrax toxin. Both the vaccines have potential side effects. The ancient veterinary anthrax vaccine waned in its potency and showed discrepancies in virulence leading to occasional death of animals ( Brossier et al., 1999; Shakya et al., 2007 ).
Journal of Biotechnology – Elsevier
Published: Apr 20, 2014
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