Generation of an infectious clone of AMDV and identification of capsid residues essential for infectivity in cell culture

Generation of an infectious clone of AMDV and identification of capsid residues essential for... •Pathogenic strains of AMDV, such as Utah-1, do not replicate in cell culture.•In this study, we constructed a full-length infectious clone (pADV-G).•Four virulence-associated residues of pADV-G VP2 were studied by mutagenesis.•Mutation of H92 or Q94 decreased transcription and replication.•VP2 residues 92 and 94 are critical for AMDV replication in vitro. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Generation of an infectious clone of AMDV and identification of capsid residues essential for infectivity in cell culture

Loading next page...
 
/lp/elsevier/generation-of-an-infectious-clone-of-amdv-and-identification-of-capsid-RjOt2ww7W6
Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2017.09.011
Publisher site
See Article on Publisher Site

Abstract

•Pathogenic strains of AMDV, such as Utah-1, do not replicate in cell culture.•In this study, we constructed a full-length infectious clone (pADV-G).•Four virulence-associated residues of pADV-G VP2 were studied by mutagenesis.•Mutation of H92 or Q94 decreased transcription and replication.•VP2 residues 92 and 94 are critical for AMDV replication in vitro.

Journal

Virus ResearchElsevier

Published: Oct 15, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off