Highlights ► Both FVB and FVB/C57B1/6 BAC mice can be used for unilaterally lesioned 6-OHDA mouse models of PD. ► In 6-OHDA mice of both strains, l -DOPA (4.5 mg/kg b.i.d.) for 21 days induces AIMs. ► The EC50 of l -DOPA is lower in FVB/C57B1/6 mice compared with pure FVB mice. ► Mouse strain must be taken into account when generating mouse models of LID. ► These models will be useful for studying mechanisms of LID in BAC transgenic mice.
Journal of Neuroscience Methods – Elsevier
Published: Apr 30, 2011
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