GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?

GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant? Molecular and Cellular Neuroscience 13, 313–325 (1999) Article ID mcne.1999.0754, available online at http://www.idealibrary.com on MCN REVIEW : Four Masters, One Servant? Matti S. Airaksinen, Alexey Titievsky, and Mart Saarma1 Program of Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikki Biocenter, FIN-00014 Helsinki, Finland GDNF FAMILY NEUROTROPHIC FACTORS Glial cell line-derived neurotrophic factor (GDNF), and related factors neurturin (NTN), artemin (ART), and persephin (PSP), are members of the GDNF family of neurotrophic factors (Fig. 1). They form a new subgroup in the transforming growth factor- (TGF- ) superfamily. These factors are basic, dimeric, secretory proteins with a cysteine knot structure (for a review see Ibanez, 1998; Saarma and Arumae, 1999). ´˜ ¨ GDNF, found as a trophic factor for midbrain dopaminergic neurons (Lin et al., 1993), has received much attention as a potential therapeutic agent for the treatment of neurodegenerative diseases (reviewed by Lapchak et al., 1997; Olson et al., 1997; Grondin and Gash, 1998). It promotes survival of many types of neurons including subpopulations of peripheral autonomic and sensory, as well as central motor, dopamine, and noradrenaline neurons (Lin et al., 1993; Henderson et al., 1994; Arenas et al., 1995; Buj-Bello et al., http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular and Cellular Neuroscience Elsevier

GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?

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Publisher
Elsevier
Copyright
Copyright © 1999 Academic Press
ISSN
1044-7431
D.O.I.
10.1006/mcne.1999.0754
Publisher site
See Article on Publisher Site

Abstract

Molecular and Cellular Neuroscience 13, 313–325 (1999) Article ID mcne.1999.0754, available online at http://www.idealibrary.com on MCN REVIEW : Four Masters, One Servant? Matti S. Airaksinen, Alexey Titievsky, and Mart Saarma1 Program of Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P.O. Box 56, Viikki Biocenter, FIN-00014 Helsinki, Finland GDNF FAMILY NEUROTROPHIC FACTORS Glial cell line-derived neurotrophic factor (GDNF), and related factors neurturin (NTN), artemin (ART), and persephin (PSP), are members of the GDNF family of neurotrophic factors (Fig. 1). They form a new subgroup in the transforming growth factor- (TGF- ) superfamily. These factors are basic, dimeric, secretory proteins with a cysteine knot structure (for a review see Ibanez, 1998; Saarma and Arumae, 1999). ´˜ ¨ GDNF, found as a trophic factor for midbrain dopaminergic neurons (Lin et al., 1993), has received much attention as a potential therapeutic agent for the treatment of neurodegenerative diseases (reviewed by Lapchak et al., 1997; Olson et al., 1997; Grondin and Gash, 1998). It promotes survival of many types of neurons including subpopulations of peripheral autonomic and sensory, as well as central motor, dopamine, and noradrenaline neurons (Lin et al., 1993; Henderson et al., 1994; Arenas et al., 1995; Buj-Bello et al.,

Journal

Molecular and Cellular NeuroscienceElsevier

Published: May 1, 1999

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