Gastric MALT lymphoma – Update on diagnosis and treatment

Gastric MALT lymphoma – Update on diagnosis and treatment Gastrointestinal lymphoma represent a heterogeneous group. The various subtypes are characterized by histological, immunohistochemical and molecular genetic properties. Aetiology, pathogenesis, biological behaviour, prognosis and treatment strategies vary widely between the different lymphoma types. Therefore, definitive diagnosis and subtyping of the lymphoma is of utmost importance for any further decision making.</P>Classification</h5> Table 1 represents the WHO classification as established in 2002 and updated in 2008 [1] . In terms of numbers, extranodal marginal zone B-cell lymphoma of MALT (mucosa-associated-lymphoid tissue) are highly predominant under the gastric lymphoma (gastric MALT lymphoma). The second most common gastric lymphoma are diffuse large B-cell lymphoma (DLBCL) with or without MALT components. In this article, I exclusively focus on gastric MALT lymphoma.</P>Pathogenesis</h5> Intensive basic and clinical research during the last three decades has substantially enriched our understanding of the development and progression of gastric MALT lymphoma. In short, mucosa-associated-lymphoid tissue (MALT) is acquired in a secondary process against Helicobacter pylori ( H. pylori ). The bacterium is the cause of chronic gastritis and leads to the formation of intramucosal lymph follicles [2,3] . There are convincing data from histomorphological, molecular biological, epidemiological and experimental studies that H. pylori is the decisive pathogenetic factor for http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Best Practice & Research Clinical Gastroenterology Elsevier

Gastric MALT lymphoma – Update on diagnosis and treatment

Loading next page...
 
/lp/elsevier/gastric-malt-lymphoma-update-on-diagnosis-and-treatment-P4mlDIHmp3
Publisher
Elsevier
Copyright
Copyright © 2014 Elsevier Ltd
ISSN
1521-6918
eISSN
1532-1916
D.O.I.
10.1016/j.bpg.2014.09.006
Publisher site
See Article on Publisher Site

Abstract

Gastrointestinal lymphoma represent a heterogeneous group. The various subtypes are characterized by histological, immunohistochemical and molecular genetic properties. Aetiology, pathogenesis, biological behaviour, prognosis and treatment strategies vary widely between the different lymphoma types. Therefore, definitive diagnosis and subtyping of the lymphoma is of utmost importance for any further decision making.</P>Classification</h5> Table 1 represents the WHO classification as established in 2002 and updated in 2008 [1] . In terms of numbers, extranodal marginal zone B-cell lymphoma of MALT (mucosa-associated-lymphoid tissue) are highly predominant under the gastric lymphoma (gastric MALT lymphoma). The second most common gastric lymphoma are diffuse large B-cell lymphoma (DLBCL) with or without MALT components. In this article, I exclusively focus on gastric MALT lymphoma.</P>Pathogenesis</h5> Intensive basic and clinical research during the last three decades has substantially enriched our understanding of the development and progression of gastric MALT lymphoma. In short, mucosa-associated-lymphoid tissue (MALT) is acquired in a secondary process against Helicobacter pylori ( H. pylori ). The bacterium is the cause of chronic gastritis and leads to the formation of intramucosal lymph follicles [2,3] . There are convincing data from histomorphological, molecular biological, epidemiological and experimental studies that H. pylori is the decisive pathogenetic factor for

Journal

Best Practice & Research Clinical GastroenterologyElsevier

Published: Dec 1, 2014

References

  • MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing the CagA protein
    Eck, M.; Schmaußer, W.; Haas, R.; Greiner, A.; Czub, S.; Müller-Hermelink, H.K.
  • Localized mucosa-associated lymphoid tissue lymphoma treated with radiation therapy has excellent clinical outcome
    Tsang, R.W.; Gospodarowicz, M.K.; Pintilie, M.
  • T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication
    Liu, H.; Ye, H.; Ruskone-Fourmestraux, A.; De Jong, D.; Pileri, S.; Thiede, C.
  • Effects of Helicobacter pylori eradication on early stage gastric mucosa-associated lymphoid tissue lymphoma
    Zullo, A.; Hassan, C.; Cristofari, F.; Andriani, A.; De Francesco, V.; Ierardi, E.
  • Second cancers and residual disease in patients treated for gastric mucosa-associated lymphoid tissue lymphoma by Helicobacter pylori eradication and followed for 10 years
    Wündisch, T.; Dieckhoff, P.; Greene, B.; Thiede, C.; Wilhelm, C.; Stolte, M.
  • Minimal residual low-grade gastric MALT-type lymphoma after eradication of Helicobacter pylori
    Fischbach, W.; Goebeler-Kolve, M.; Starostik, P.; Greiner, A.; Müller-Hermelink, H.K.
  • Comparison of localized gastric mucosa-associated lymphoid (MALT) lymphoma with and without Helicobacter pylori infection
    Akamatsu, T.; Mochizuki, T.; Okiyama, Y.; Matsumoto, A.; Miyabayashi, H.; Ota, H.
  • Long-term clinical outcome of Helicobacter pylori -negative gastric mucosa-associated lymphoid tissue lymphoma is comparable to that of H. pylori -positive lymphoma
    Chung, S.J.; Kim, J.S.; Kim, H.; Kim, S.G.; Kim, C.W.; Jung, H.C.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off