Gastrointestinal lymphoma represent a heterogeneous group. The various subtypes are characterized by histological, immunohistochemical and molecular genetic properties. Aetiology, pathogenesis, biological behaviour, prognosis and treatment strategies vary widely between the different lymphoma types. Therefore, definitive diagnosis and subtyping of the lymphoma is of utmost importance for any further decision making.</P>Classification</h5> Table 1 represents the WHO classification as established in 2002 and updated in 2008  . In terms of numbers, extranodal marginal zone B-cell lymphoma of MALT (mucosa-associated-lymphoid tissue) are highly predominant under the gastric lymphoma (gastric MALT lymphoma). The second most common gastric lymphoma are diffuse large B-cell lymphoma (DLBCL) with or without MALT components. In this article, I exclusively focus on gastric MALT lymphoma.</P>Pathogenesis</h5> Intensive basic and clinical research during the last three decades has substantially enriched our understanding of the development and progression of gastric MALT lymphoma. In short, mucosa-associated-lymphoid tissue (MALT) is acquired in a secondary process against Helicobacter pylori ( H. pylori ). The bacterium is the cause of chronic gastritis and leads to the formation of intramucosal lymph follicles [2,3] . There are convincing data from histomorphological, molecular biological, epidemiological and experimental studies that H. pylori is the decisive pathogenetic factor for
Best Practice & Research Clinical Gastroenterology – Elsevier
Published: Dec 1, 2014
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