Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway

Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the... •GM1 alleviates brain edema in rats upon acute hypobaric hypoxia (HH) condition.•GM1 effectively counters HH-induced cognitive decline and motor deficits.•GM1 administration antagonizes oxidative stress in rat brains during HH.•Treatment with GM1 blunts HH-evoked inflammatory response.•Blocking PI3K/AKT pathway attenuates GM1-ameliorated high altitude brain edema. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway

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Publisher
Pergamon
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.02.001
Publisher site
See Article on Publisher Site

Abstract

•GM1 alleviates brain edema in rats upon acute hypobaric hypoxia (HH) condition.•GM1 effectively counters HH-induced cognitive decline and motor deficits.•GM1 administration antagonizes oxidative stress in rat brains during HH.•Treatment with GM1 blunts HH-evoked inflammatory response.•Blocking PI3K/AKT pathway attenuates GM1-ameliorated high altitude brain edema.

Journal

Molecular ImmunologyElsevier

Published: Mar 1, 2018

References

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