GABA A (γ-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA A receptors in seizure disorders. In particular, genetic mutations found in GABA A receptor subunits strongly implicate the GABA A receptor in idiopathic generalised epilepsies.
Current Opinion in Pharmacology – Elsevier
Published: Feb 1, 2003
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