GABA A receptor function and pharmacology in epilepsy and status epilepticus

GABA A receptor function and pharmacology in epilepsy and status epilepticus GABA A (γ-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA A receptors in seizure disorders. In particular, genetic mutations found in GABA A receptor subunits strongly implicate the GABA A receptor in idiopathic generalised epilepsies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Pharmacology Elsevier

GABA A receptor function and pharmacology in epilepsy and status epilepticus

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Ltd
ISSN
1471-4892
D.O.I.
10.1016/S1471-4892(02)00015-2
Publisher site
See Article on Publisher Site

Abstract

GABA A (γ-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA A receptors in seizure disorders. In particular, genetic mutations found in GABA A receptor subunits strongly implicate the GABA A receptor in idiopathic generalised epilepsies.

Journal

Current Opinion in PharmacologyElsevier

Published: Feb 1, 2003

References

  • Structure and subunit composition of GABA A receptors
    Sieghart, W.; Fuchs, K.; Tretter, V.; Ebert, V.; Jechlinger, M.; Hoger, H.; Adamiker, D.
  • Acute cellular alterations in the hippocampus after status epilepticus
    Macdonald, R.L.; Kapur, J.
  • Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus
    Jones, D.; Esmaeil, N.; Maren, S.; Macdonald, R.
  • GABAergic neurons and GABA A -receptors in temporal lobe epilepsy
    Fritschy, J.M.; Kiener, T.; Bouilleret, V.; Loup, F.
  • Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting
    Mello, L.E.; Cavalheiro, E.A.; Tan, A.M.; Kupfer, W.R.; Pretorius, J.K.; Babb, T.L.; Finch, D.M.
  • Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents
    Holland, K.D.; McKeon, A.C.; Canney, D.J.; Covey, D.F.; Ferrendelli, J.A.
  • Status epilepticus related to alcohol abuse
    Alldredge, B.K.; Lowenstein, D.H.

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