Functional characteristics of heterologously expressed 5-HT receptors

Functional characteristics of heterologously expressed 5-HT receptors Over the past 10 years, molecular cloning has revealed the presence of 15 serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes, which can be subdivided in seven subfamilies. Except for the 5-HT 3 receptors, which are ligand-gated ion channels, all 5-HT receptors belong to the superfamily of G-protein-coupled receptors. The large multiplicity of 5-HT receptor subtypes has been suggested to be a direct result of the evolutionary age of the 5-HT system. Molecular information on G-protein-coupled 5-HT receptors is currently available for several mammalian species as well as for a limited number of invertebrate species (insects, molluscs). The aim of this review is to give an overview of all cloned 5-HT receptor subtypes belonging to the superfamily of G-protein-coupled receptors with specific emphasis on the pharmacological and signaling properties of the receptors upon expression in several heterologous expression systems. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Functional characteristics of heterologously expressed 5-HT receptors

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science B.V.
ISSN
0014-2999
DOI
10.1016/S0014-2999(97)01115-1
Publisher site
See Article on Publisher Site

Abstract

Over the past 10 years, molecular cloning has revealed the presence of 15 serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes, which can be subdivided in seven subfamilies. Except for the 5-HT 3 receptors, which are ligand-gated ion channels, all 5-HT receptors belong to the superfamily of G-protein-coupled receptors. The large multiplicity of 5-HT receptor subtypes has been suggested to be a direct result of the evolutionary age of the 5-HT system. Molecular information on G-protein-coupled 5-HT receptors is currently available for several mammalian species as well as for a limited number of invertebrate species (insects, molluscs). The aim of this review is to give an overview of all cloned 5-HT receptor subtypes belonging to the superfamily of G-protein-coupled receptors with specific emphasis on the pharmacological and signaling properties of the receptors upon expression in several heterologous expression systems.

Journal

European Journal of PharmacologyElsevier

Published: Sep 3, 1997

References

  • Regulation of high-conductance anion channels by G-proteins and 5-HT1A receptors in CHO cells
    Mangel, A.W.; Raymond, J.R.; Fitz, J.G.
  • Gene structure and expression of the mouse 5-HT2 receptor
    Yang, W.; Chen, K.; Lan, N.C.; Gallaher, T.K.; Shih, J.C.
  • 5-Hydroxytryptamine receptors
    Zifa, E.; Fillion, G.

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