Function of Cannabinoid Receptors in the Neuroendocrine Regulation of Hormone Secretion

Function of Cannabinoid Receptors in the Neuroendocrine Regulation of Hormone Secretion Marijuana and its cannabinoid constituents have profound effects on anterior pituitary hormone secretion. Exposure to Δ 9 -tetrahydrocannabinol inhibits gonadotropin, prolactin, growth hormone, and thyroid-stimulating hormone release and stimulates the release of corticotropin. Consequently, cannabinoid exposure could have profound effects on the function of the reproductive system, lactation, metabolism, and on the endocrine stress axis. The acute effects of cannabinoids on the endocrine system are consistent with its actions on brain neurotransmitter systems involved in the regulation of neuropeptides that modulate anterior pituitary hormone secretion. Although cannabinoid receptors appear to play a major role in the ability of cannabinoids to influence hormone release, much remains to be learned concerning their function in the neuroendocrine regulation of hormone secretion. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neurobiology of Disease Elsevier

Function of Cannabinoid Receptors in the Neuroendocrine Regulation of Hormone Secretion

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Publisher
Elsevier
Copyright
Copyright © 1998 Academic Press
ISSN
0969-9961
eISSN
1095-953X
D.O.I.
10.1006/nbdi.1998.0224
Publisher site
See Article on Publisher Site

Abstract

Marijuana and its cannabinoid constituents have profound effects on anterior pituitary hormone secretion. Exposure to Δ 9 -tetrahydrocannabinol inhibits gonadotropin, prolactin, growth hormone, and thyroid-stimulating hormone release and stimulates the release of corticotropin. Consequently, cannabinoid exposure could have profound effects on the function of the reproductive system, lactation, metabolism, and on the endocrine stress axis. The acute effects of cannabinoids on the endocrine system are consistent with its actions on brain neurotransmitter systems involved in the regulation of neuropeptides that modulate anterior pituitary hormone secretion. Although cannabinoid receptors appear to play a major role in the ability of cannabinoids to influence hormone release, much remains to be learned concerning their function in the neuroendocrine regulation of hormone secretion.

Journal

Neurobiology of DiseaseElsevier

Published: Dec 1, 1998

References

  • Characterization of the acute endocrine actions of HU-210, a potent synthetic cannabinoid in rats
    Martı́n-Calderón, J.L.; Muñoz, R.M.; Villanúa, M.A.; del Arco, I.; Moreno, J.L.; Rodrı́guez de Fonseca, F.; Navarro, M.
  • Direct antigonadal activity of cannabinoids: Suppression of rat granulosa cell functions
    Adashi, E.Y.; Jones, P.B.C.; Hsueh, A.J.W.
  • The effect of 1- trans 9
    Dewey, W.L.; Peng, T.C.; Harris, L.C.
  • The effects of chronic cannabis treatment upon brain 5-hydroxytryptamine, plasma corticosterone and aggressive behavior in female rats with different hormonal status
    Neto, J.P.; Nunes, J.F.; Carvalho, F.V.
  • Characterization of the synthetic cannabinoid HU-210 in the rat. Relation to the adrenergic system and endogenous pyrogens
    Ovadia, H.; Wohlman, A.; Mechoulam, R.; Weidenfeld, J.

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