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as a targeted agent for the imaging of tumors that overexpress the folate receptor . Folic acid was conjugated to PL-Gd-DTPA via the ε-amino groups. The receptor binding properties of folate -PL-Gd-DTPA were ...
the potential to localize therapeutic agents to a specific make these luminomagnetic nanocarriers one of the tissue as a mechanism to enhance treatment efficacy and most feasible candidates for folate receptor ...
exploited for targeting 1 1 2 imaging and therapeutic agents to these cells (15). Michael D. Kennedy, Karim N. Jallad, June Lu, 1 1,3 Although folate receptors expressed in the kidney proxi- Philip S. Low ...
Overexpression of folate receptors (FRs) on different tumor types (e.g., ovarian, lung) make FRs attractive in vivo targets for directed diagnostic/ therapeutic agents . Currently, no diagnostic agent ...
in folate release that is required for metabolic synthesis of DNA and RNA. Abbreviation: FR, folate receptor . Early efforts to therapeutically target FRα included the humanized anti‐FRα monoclonal antibody ...
under different physiological conditions have been well studied. Finally, the developed system was tested for its therapeutic efficacy using cancer cells, in vitro. The receptor mediated cell uptake ...
imaging probes CT/MR imaging of folate receptors (FAR) of cancer cells [113] Polyethylene-imines (PEIs) (PEG), non-covalent complexes with siRNA Active Therapeutic siRNAs RNAi- mediated gene targeting ...
exceptionally strong host–guest chemistry; 2) high structural stability; 3) facile internalization into targeted cells by receptor ‐ mediated endocytosis, and 4) efficient triggered release of entrapped drugs ...
to normal cells. Folate receptors are expressed in a variety of cancer cells. Folic acid mediated targeting is a well accepted technique for cancer therapeutics . The purpose of this study is to explore ...
, Crane LM, et al. Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor -α targeting : first in-human results . Nat Med. 2011;17(10):1315-1319.PubMedGoogle ScholarCrossref 8 ...
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