Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics

Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics Rapid scavenging of the model stable radical cation, ABTS •+ , has been applied to screen for the antioxidant activity of flavonoids. The reaction follows two distinct phases. For compounds with a monophenolic B-ring there is a rapid initial phase of reduction of ABTS •+ within 0.1 s with no further change in the subsequent 2.9 s. In contrast, compounds with a catechol-containing B ring follow a fast initial scavenging phase with a slow secondary phase. Flavonoids with an unsubstituted B ring do not react within this time scale. The findings suggest that the structure of the B ring is the primary determinant of the antioxidant activity of flavonoids when studied through fast reaction kinetics. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Biochemical and Biophysical Research Communications Elsevier

Flavonoid B-Ring Chemistry and Antioxidant Activity: Fast Reaction Kinetics

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Publisher
Elsevier
Copyright
Copyright © 2001 Academic Press
ISSN
0006-291x
DOI
10.1006/bbrc.2001.4705
Publisher site
See Article on Publisher Site

Abstract

Rapid scavenging of the model stable radical cation, ABTS •+ , has been applied to screen for the antioxidant activity of flavonoids. The reaction follows two distinct phases. For compounds with a monophenolic B-ring there is a rapid initial phase of reduction of ABTS •+ within 0.1 s with no further change in the subsequent 2.9 s. In contrast, compounds with a catechol-containing B ring follow a fast initial scavenging phase with a slow secondary phase. Flavonoids with an unsubstituted B ring do not react within this time scale. The findings suggest that the structure of the B ring is the primary determinant of the antioxidant activity of flavonoids when studied through fast reaction kinetics.

Journal

Biochemical and Biophysical Research CommunicationsElsevier

Published: Apr 20, 2001

References

  • Applicability of an improved Trolox equivalent antioxidant capacity (TEAC) assay for evaluation of antioxidant capacity measurements of mixtures
    van den Berg, R.; Haenen, G.R.M.M.; van den Berg, H.; Bast, A.
  • Flavonoids as antioxidants
    Jovanovic, S.V.; Steenken, S.; Tosic, M.; Marjanovic, B.; Simic, M.G.
  • Oxygen activation during peroxidase catalysed metabolism of flavones or flavanones
    Chan, T.; Galati, G.; O'Brien, P.J.

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