Acta Biomaterialia 71 (2018) 318–329 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Fibrin glue mesh ﬁxation combined with mesenchymal stem cells or exosomes modulates the inﬂammatory reaction in a murine model of incisional hernia a,b,1 a,b,1 a a Rebeca Blázquez , Francisco Miguel Sánchez-Margallo , Verónica Álvarez , Alejandra Usón , a a,b,c,⇑ Federica Marinaro , Javier G. Casado Stem Cell Therapy Unit, ‘Jesús Usón’ Minimally Invasive Surgery Centre, Cáceres 10071, Spain CIBER de Enfermedades Cardiovasculares, Spain Immunology Unit, Department of Physiology, University of Extremadura, 10071 Caceres, Spain ar ti c l e i nf o ab stra ct Article history: Surgical meshes are effective and frequently used to reinforce soft tissues. Fibrin glue (FG) has been Received 6 November 2017 widely used for mesh ﬁxation and is also considered an optimal vehicle for stem cell delivery. The aim Received in revised form 9 February 2018 of this preclinical study was to evaluate the therapeutic effect of MSCs and their exosomes combined Accepted 12 February 2018 with FG for the treatment of incisional hernia. Available online 17 February 2018 A murine incisional hernia model was used to implant surgical meshes and different treatments
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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