Article history: The ability to topographically mimic the surface features of collagen ﬁbrils is an important step in the Received 14 April 2017 preparation of tissue engineering scaffolds. It is important to know which kinds of surface topographies of Received in revised form 25 July 2017 electrospun ﬁbers are more favorable for cell growth. In this study, ﬁbers with three kinds of hierarchical- Accepted 1 August 2017 structured surfaces were fabricated by electrospinning to mimic collagen ﬁbrils. By combining thermally Available online 5 August 2017 induced phase separation (TIPS) and non-solvent induced phase separation (NIPS), polycaprolactone (PCL) ﬁbers with a porous surface were electrospun from PCL in a chloroform (CF)/dimethyl sulfoxide Keywords: (DMSO) mixed solution. In addition, two additional types of ﬁbrous membranes, with PCL ﬁbers being the Poly(-caprolactone) (PCL) electrospun shish and decorated by PCL kebabs on the surface, were created by two different controlled homoepitaxic nanoﬁbers crystallization methods—the solution incubation method and the solvent evaporation method. It was Nanoporous structured ﬁber found that the solvent evaporation method was more effective in forming kebabs and the primary optimal Shish-kebab structured ﬁber Tissue engineering processing parameters were identiﬁed. The presence of pores on the ﬁber surfaces contributed to a
Applied Surface Science – Elsevier
Published: Jan 1, 2018
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