Fabrication of polycaprolactone electrospun fibers with different hierarchical structures mimicking collagen fibrils for tissue engineering scaffolds

Fabrication of polycaprolactone electrospun fibers with different hierarchical structures... Article history: The ability to topographically mimic the surface features of collagen fibrils is an important step in the Received 14 April 2017 preparation of tissue engineering scaffolds. It is important to know which kinds of surface topographies of Received in revised form 25 July 2017 electrospun fibers are more favorable for cell growth. In this study, fibers with three kinds of hierarchical- Accepted 1 August 2017 structured surfaces were fabricated by electrospinning to mimic collagen fibrils. By combining thermally Available online 5 August 2017 induced phase separation (TIPS) and non-solvent induced phase separation (NIPS), polycaprolactone (PCL) fibers with a porous surface were electrospun from PCL in a chloroform (CF)/dimethyl sulfoxide Keywords: (DMSO) mixed solution. In addition, two additional types of fibrous membranes, with PCL fibers being the Poly(-caprolactone) (PCL) electrospun shish and decorated by PCL kebabs on the surface, were created by two different controlled homoepitaxic nanofibers crystallization methods—the solution incubation method and the solvent evaporation method. It was Nanoporous structured fiber found that the solvent evaporation method was more effective in forming kebabs and the primary optimal Shish-kebab structured fiber Tissue engineering processing parameters were identified. The presence of pores on the fiber surfaces contributed to a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied Surface Science Elsevier

Fabrication of polycaprolactone electrospun fibers with different hierarchical structures mimicking collagen fibrils for tissue engineering scaffolds

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0169-4332
eISSN
1873-5584
D.O.I.
10.1016/j.apsusc.2017.08.005
Publisher site
See Article on Publisher Site

Abstract

Article history: The ability to topographically mimic the surface features of collagen fibrils is an important step in the Received 14 April 2017 preparation of tissue engineering scaffolds. It is important to know which kinds of surface topographies of Received in revised form 25 July 2017 electrospun fibers are more favorable for cell growth. In this study, fibers with three kinds of hierarchical- Accepted 1 August 2017 structured surfaces were fabricated by electrospinning to mimic collagen fibrils. By combining thermally Available online 5 August 2017 induced phase separation (TIPS) and non-solvent induced phase separation (NIPS), polycaprolactone (PCL) fibers with a porous surface were electrospun from PCL in a chloroform (CF)/dimethyl sulfoxide Keywords: (DMSO) mixed solution. In addition, two additional types of fibrous membranes, with PCL fibers being the Poly(-caprolactone) (PCL) electrospun shish and decorated by PCL kebabs on the surface, were created by two different controlled homoepitaxic nanofibers crystallization methods—the solution incubation method and the solvent evaporation method. It was Nanoporous structured fiber found that the solvent evaporation method was more effective in forming kebabs and the primary optimal Shish-kebab structured fiber Tissue engineering processing parameters were identified. The presence of pores on the fiber surfaces contributed to a

Journal

Applied Surface ScienceElsevier

Published: Jan 1, 2018

References

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