Available online at www.sciencedirect.com ScienceDirect Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors Jennifer Brooke Treweek and Viviana Gradinaru The scientiﬁc community has learned a great deal from imaging aspects of a diverse range of organisms in great detail, small and naturally transparent organisms such as nematodes scientists have been able to amass a set of unifying and zebraﬁsh. The consequences of genetic mutations on their principles for the ﬁeld of neural sciences . The route organ development and survival can be visualized easily and to this understanding parallels the hermeneutic circle, a with high-throughput at the organism-wide scale. In contrast, classic concept in theology and logic . In hermeneutics, three-dimensional information is less accessible in mammalian the process of interpretation follows a spiraling path in subjects because the heterogeneity of light-scattering tissue which one ﬁrst studies the overall body, then examines its elements renders their organs opaque. Likewise, genetically composite parts, and lastly revisits the concept of the labeling desired circuits across mammalian bodies is whole body as a sum of the parts. Similarly, in neurosci- prohibitively slow and costly via the transgenic route. Emerging ence,
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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