Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors

Extracting structural and functional features of widely distributed biological circuits with... Available online at www.sciencedirect.com ScienceDirect Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors Jennifer Brooke Treweek and Viviana Gradinaru The scientific community has learned a great deal from imaging aspects of a diverse range of organisms in great detail, small and naturally transparent organisms such as nematodes scientists have been able to amass a set of unifying and zebrafish. The consequences of genetic mutations on their principles for the field of neural sciences [2]. The route organ development and survival can be visualized easily and to this understanding parallels the hermeneutic circle, a with high-throughput at the organism-wide scale. In contrast, classic concept in theology and logic [3]. In hermeneutics, three-dimensional information is less accessible in mammalian the process of interpretation follows a spiraling path in subjects because the heterogeneity of light-scattering tissue which one first studies the overall body, then examines its elements renders their organs opaque. Likewise, genetically composite parts, and lastly revisits the concept of the labeling desired circuits across mammalian bodies is whole body as a sum of the parts. Similarly, in neurosci- prohibitively slow and costly via the transgenic route. Emerging ence, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Biotechnology Elsevier

Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0958-1669
D.O.I.
10.1016/j.copbio.2016.03.012
Publisher site
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Abstract

Available online at www.sciencedirect.com ScienceDirect Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors Jennifer Brooke Treweek and Viviana Gradinaru The scientific community has learned a great deal from imaging aspects of a diverse range of organisms in great detail, small and naturally transparent organisms such as nematodes scientists have been able to amass a set of unifying and zebrafish. The consequences of genetic mutations on their principles for the field of neural sciences [2]. The route organ development and survival can be visualized easily and to this understanding parallels the hermeneutic circle, a with high-throughput at the organism-wide scale. In contrast, classic concept in theology and logic [3]. In hermeneutics, three-dimensional information is less accessible in mammalian the process of interpretation follows a spiraling path in subjects because the heterogeneity of light-scattering tissue which one first studies the overall body, then examines its elements renders their organs opaque. Likewise, genetically composite parts, and lastly revisits the concept of the labeling desired circuits across mammalian bodies is whole body as a sum of the parts. Similarly, in neurosci- prohibitively slow and costly via the transgenic route. Emerging ence,

Journal

Current Opinion in BiotechnologyElsevier

Published: Aug 1, 2016

References

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