Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis

Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. Transferring biological information via EVs to neighboring cells and inter-cellular communication not only maintain physiological functions, but also involve in the pathogenesis of several diseases, including cancer. The aim of this review is to discuss the emerging role of EVs in viral hepatitis, non-alcoholic or alcoholic liver disease and liver cancers. We summarize what is known about exosome biogenesis, and role in liver disease progression, and discuss the potential clinical applications of EVs as predictive biomarkers and therapeutic modalities. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Aspects of Medicine Elsevier

Extracellular vesicles: Novel mediator for cell to cell communications in liver pathogenesis

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
0098-2997
eISSN
1872-9452
D.O.I.
10.1016/j.mam.2017.11.001
Publisher site
See Article on Publisher Site

Abstract

Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. Transferring biological information via EVs to neighboring cells and inter-cellular communication not only maintain physiological functions, but also involve in the pathogenesis of several diseases, including cancer. The aim of this review is to discuss the emerging role of EVs in viral hepatitis, non-alcoholic or alcoholic liver disease and liver cancers. We summarize what is known about exosome biogenesis, and role in liver disease progression, and discuss the potential clinical applications of EVs as predictive biomarkers and therapeutic modalities.

Journal

Molecular Aspects of MedicineElsevier

Published: Apr 1, 2018

References

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