Extracellular matrix and its interactions in the diabetic kidney: A molecular biological approach

Extracellular matrix and its interactions in the diabetic kidney: A molecular biological approach Increased extracellular matrix (ECM) is the ultrastructural hallmark of diabetic microangiopathy. Its accumulation within the kidney is directly linked to the clinical manifestations of diabetic nephropathy, namely proteinuria and declining renal function. The pathogenesis of ECM changes in diabetes is not well understood, but is likely to involve interaction between cells, growth factors, structural proteins, and cell receptors for these molecules. Molecular biological techniques may offer the necessary tools for gaining insight into the pathogenetic processes that eventually lead to renal failure in diabetes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Diabetes and its Complications Elsevier

Extracellular matrix and its interactions in the diabetic kidney: A molecular biological approach

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
1056-8727
DOI
10.1016/1056-8727(95)80015-7
Publisher site
See Article on Publisher Site

Abstract

Increased extracellular matrix (ECM) is the ultrastructural hallmark of diabetic microangiopathy. Its accumulation within the kidney is directly linked to the clinical manifestations of diabetic nephropathy, namely proteinuria and declining renal function. The pathogenesis of ECM changes in diabetes is not well understood, but is likely to involve interaction between cells, growth factors, structural proteins, and cell receptors for these molecules. Molecular biological techniques may offer the necessary tools for gaining insight into the pathogenetic processes that eventually lead to renal failure in diabetes.

Journal

Journal of Diabetes and its ComplicationsElsevier

Published: Oct 1, 1995

References

  • Increased distal nephron EGF content and altered distribution of peptide in compensatory renal hypertrophy
    Miller, SB; Rogers, SA; Estes, CE; Hammerman, MR

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