Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina

Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and... The expression of mRNA coding for brain-derived neurotrophic factor (BDNF) and for its functional receptor, the full-length tyrosine kinase receptor trkB ( trk B mRNA), was examined in early postnatal and adult rat retina by in situ hybridization using digoxygenin and radioactively-labeled oligonucleotide probes. BDNF and trk B mRNAs are expressed in the ganglion cell layer at postnatal-days (PN) 1, 4, 7, 14, 60, in proximal neuroblastic layer (PN 1, 4, 7), and proximal inner nuclear layer (PN 14, 60). Subpopulations of developing and mature retinal cells are thus capable of synthesizing BDNF. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Expression of brain-derived neurotrophic factor and of its functional receptor in neonatal and adult rat retina

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0304-3940
D.O.I.
10.1016/0304-3940(94)11123-Z
Publisher site
See Article on Publisher Site

Abstract

The expression of mRNA coding for brain-derived neurotrophic factor (BDNF) and for its functional receptor, the full-length tyrosine kinase receptor trkB ( trk B mRNA), was examined in early postnatal and adult rat retina by in situ hybridization using digoxygenin and radioactively-labeled oligonucleotide probes. BDNF and trk B mRNAs are expressed in the ganglion cell layer at postnatal-days (PN) 1, 4, 7, 14, 60, in proximal neuroblastic layer (PN 1, 4, 7), and proximal inner nuclear layer (PN 14, 60). Subpopulations of developing and mature retinal cells are thus capable of synthesizing BDNF.

Journal

Neuroscience LettersElsevier

Published: Jan 2, 1995

References

  • Cells that express brain-derived neurotrophic factor mRNA in the developing postnatal rat brain
    Friedman, W.J.; Olson, L.; Persson, H.

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