Exon Skipping Is Correlated with Exon Circularization

Exon Skipping Is Correlated with Exon Circularization Circular RNAs are found in a wide range of organisms and it has been proposed that they perform disparate functions. However, how RNA circularization is connected to alternative splicing remains largely unexplored. Here, we stimulated primary human endothelial cells with tumor necrosis factor α or tumor growth factor β, purified RNA, generated >2.4 billion RNA-seq reads, and used a custom pipeline to characterize circular RNAs derived from coding exons. We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Molecular Biology Elsevier

Exon Skipping Is Correlated with Exon Circularization

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Publisher
Academic Press
Copyright
Copyright © 2015 Elsevier Ltd
ISSN
0022-2836
D.O.I.
10.1016/j.jmb.2015.02.018
Publisher site
See Article on Publisher Site

Abstract

Circular RNAs are found in a wide range of organisms and it has been proposed that they perform disparate functions. However, how RNA circularization is connected to alternative splicing remains largely unexplored. Here, we stimulated primary human endothelial cells with tumor necrosis factor α or tumor growth factor β, purified RNA, generated >2.4 billion RNA-seq reads, and used a custom pipeline to characterize circular RNAs derived from coding exons. We find that circularization of exons is widespread and correlates with exon skipping, a feature that adds considerably to the regulatory complexity of the human transcriptome.

Journal

Journal of Molecular BiologyElsevier

Published: Jul 31, 2015

References

  • Circular RNAs are a large class of animal RNAs with regulatory potency
    Memczak, S.; Jens, M.; Elefsinioti, A.; Torti, F.; Krueger, J.; Rybak, A.
  • Natural RNA circles function as efficient microRNA sponges
    Hansen, T.B.; Jensen, T.I.; Clausen, B.H.; Bramsen, J.B.; Finsen, B.; Damgaard, C.K.

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