Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers

Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers Elite swimmers have an increased risk of developing asthma, and exposure to chloramine is believed to be an important trigger factor. The aim of the present study was to explore pathophysiological mechanisms behind induced bronchoconstriction in swimmers exposed to chloramine, before and after swim exercise provocation as well as mannitol provocation. Urinary Clara cell protein (CC16) was used as a possible marker for epithelial stress. 101 elite aspiring swim athletes were investigated and urinary samples were collected before and 1 h after completed exercise and mannitol challenge. CC16, 11β-prostaglandin (PG)F 2α and leukotriene E 4 (LTE 4 ) were measured. Urinary levels of CC16 were clearly increased after exercise challenge, while no reaction was seen after mannitol challenge. Similar to CC16, the level of 11β-PGF 2α was increased after exercise challenge, but not after mannitol challenge, while LTE 4 was reduced after exercise. There was no significant difference in urinary response between those with a negative compared to positive challenge, but a tendency of increased baseline levels of 11β-PGF 2α and LTE 4 in individuals with a positive mannitol challenge. The uniform increase of CC16 after swim exercise indicates that CC16 is of importance in epithelial stress, and may as such be an important pathogenic factor behind asthma development in swimmers. The changes seen in urinary levels of 11β-PGF 2α and LTE 4 indicate a pathophysiological role in both mannitol and exercise challenge. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Respiratory Medicine Elsevier

Exercise but not mannitol provocation increases urinary Clara cell protein (CC16) in elite swimmers

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Publisher
Elsevier
Copyright
Copyright © 2010 Elsevier Ltd
ISSN
0954-6111
D.O.I.
10.1016/j.rmed.2010.07.012
Publisher site
See Article on Publisher Site

References

  • Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker
    Broeckaert, F.; Bernard, A.
  • Role of leukotrienes in exercise-induced bronchoconstriction
    Hallstrand, T.S.; Henderson, W.R.
  • Methods for "indirect" challenge tests including exercise, eucapnic voluntary hyperpnea, and hypertonic aerosols
    Anderson, S.D.; Brannan, J.D.
  • Methodological aspects on measurement of Clara cell protein in urine as a biomarker for airway toxicity, compared with serum levels
    Andersson, L.; Lundberg, P.A.; Barregard, L.

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