Excitatory amino acids and drugs of abuse: a role for N -methyl- d -aspartate receptors in drug tolerance, sensitization and physical dependence

Excitatory amino acids and drugs of abuse: a role for N -methyl- d -aspartate receptors in drug... N -methyl- d -aspartate (NMDA) receptors have been implicated in several types of neural and behavioral plasticity ranging from development to learning. The present paper reviews evidence suggesting that these receptors might also be involved in the neural and behavioral changes resulting from chronic administration of drugs of abuse. NMDA receptor antagonists have been found to interfere with tolerance, sensitization, physical dependence and conditioning to a variety of self-administered drugs, including psychomotor stimulants, opiates, ethanol and nicotine. The results indicate a broad role for NMDA receptors in drug-induced neural and behavioral plasticity, including changes in the brain and behavior that may lead to compulsive drug use, and suggest that drugs acting at the NMDA receptor complex may be clinically useful. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Drug and Alcohol Dependence Elsevier

Excitatory amino acids and drugs of abuse: a role for N -methyl- d -aspartate receptors in drug tolerance, sensitization and physical dependence

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0376-8716
DOI
10.1016/0376-8716(95)01119-J
Publisher site
See Article on Publisher Site

Abstract

N -methyl- d -aspartate (NMDA) receptors have been implicated in several types of neural and behavioral plasticity ranging from development to learning. The present paper reviews evidence suggesting that these receptors might also be involved in the neural and behavioral changes resulting from chronic administration of drugs of abuse. NMDA receptor antagonists have been found to interfere with tolerance, sensitization, physical dependence and conditioning to a variety of self-administered drugs, including psychomotor stimulants, opiates, ethanol and nicotine. The results indicate a broad role for NMDA receptors in drug-induced neural and behavioral plasticity, including changes in the brain and behavior that may lead to compulsive drug use, and suggest that drugs acting at the NMDA receptor complex may be clinically useful.

Journal

Drug and Alcohol DependenceElsevier

Published: May 1, 1995

References

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