Evolution of transcription factor function

Evolution of transcription factor function Functional assays in Drosophila melanogaster with orthologous transcription factors from other species suggest that changes in the protein-coding sequence may play a larger role in the evolution of transcription factor pathways than was previously believed. Interestingly, recent studies provide evidence that changes in transcription factor protein sequence can affect the regulation of only a subset of target genes, even in the same cells of a developing animal. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Genetics & Development Elsevier

Evolution of transcription factor function

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Science Ltd
ISSN
0959-437x
D.O.I.
10.1016/S0959-437X(03)00017-0
Publisher site
See Article on Publisher Site

Abstract

Functional assays in Drosophila melanogaster with orthologous transcription factors from other species suggest that changes in the protein-coding sequence may play a larger role in the evolution of transcription factor pathways than was previously believed. Interestingly, recent studies provide evidence that changes in transcription factor protein sequence can affect the regulation of only a subset of target genes, even in the same cells of a developing animal.

Journal

Current Opinion in Genetics & DevelopmentElsevier

Published: Apr 1, 2003

References

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