•Pituitary transcription factor POU1F1 evolution studied using data from 113 mammals.•Domains of POU1F1 evolve at different rates but the overall rate is quite slow.•Rapid evolution of β-domain and low expression of β-variant suggest lack of function.•In some species β-domain contains mutations preventing normal translation.•Results suggest that β-splice-variant lacks physiological significance in mammals.
General and Comparative Endocrinology – Elsevier
Published: May 1, 2018
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