Evolution of the POU1F1 transcription factor in mammals: Rapid change of the alternatively-spliced β-domain

Evolution of the POU1F1 transcription factor in mammals: Rapid change of the... •Pituitary transcription factor POU1F1 evolution studied using data from 113 mammals.•Domains of POU1F1 evolve at different rates but the overall rate is quite slow.•Rapid evolution of β-domain and low expression of β-variant suggest lack of function.•In some species β-domain contains mutations preventing normal translation.•Results suggest that β-splice-variant lacks physiological significance in mammals. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png General and Comparative Endocrinology Elsevier

Evolution of the POU1F1 transcription factor in mammals: Rapid change of the alternatively-spliced β-domain

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
0016-6480
D.O.I.
10.1016/j.ygcen.2018.01.005
Publisher site
See Article on Publisher Site

Abstract

•Pituitary transcription factor POU1F1 evolution studied using data from 113 mammals.•Domains of POU1F1 evolve at different rates but the overall rate is quite slow.•Rapid evolution of β-domain and low expression of β-variant suggest lack of function.•In some species β-domain contains mutations preventing normal translation.•Results suggest that β-splice-variant lacks physiological significance in mammals.

Journal

General and Comparative EndocrinologyElsevier

Published: May 1, 2018

References

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