Molecular Phylogenetics and Evolution 120 (2018) 364–374 Contents lists available at ScienceDirect Molecular Phylogenetics and Evolution journal homepage: www.elsevier.com/locate/ympev Editor’s Choice Article Evolution of the MC5R gene in placental mammals with evidence for its inactivation in multiple lineages that lack sebaceous glands a, b Mark S. Springer , John Gatesy Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 92521, USA Division of Vertebrate Zoology, American Museum of Natural History, New York, NY 10024, USA ARTICLE I NFO ABSTRACT Keywords: MC5R is one of ﬁve melanocortin receptor genes found in placental mammals. MC5R plays an important role in Cetacea energy homeostasis and is also expressed in the terminal diﬀerentiation of sebaceous glands. Among placental Mammuthus mammals there are multiple lineages that either lack or have degenerative sebaceous glands including Cetacea MC5R (whales, dolphins, and porpoises), Hippopotamidae (hippopotamuses), Sirenia (manatees and dugongs), Pseudogenes Proboscidea (elephants), Rhinocerotidae (rhinos), and Heterocephalus glaber (naked mole rat). Given the loss or Sebaceous glands diminution of sebaceous glands in these taxa, we procured MC5R sequences from publicly available genomes and transcriptomes, supplemented by a newly generated sequence for Choeropsis liberiensis (pygmy hippopotamus), to determine if this gene remains intact or is inactivated
Molecular Phylogenetics and Evolution – Elsevier
Published: Mar 1, 2018
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