Evolution of the MC5R gene in placental mammals with evidence for its inactivation in multiple lineages that lack sebaceous glands

Evolution of the MC5R gene in placental mammals with evidence for its inactivation in multiple... Molecular Phylogenetics and Evolution 120 (2018) 364–374 Contents lists available at ScienceDirect Molecular Phylogenetics and Evolution journal homepage: www.elsevier.com/locate/ympev Editor’s Choice Article Evolution of the MC5R gene in placental mammals with evidence for its inactivation in multiple lineages that lack sebaceous glands a, b Mark S. Springer , John Gatesy Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 92521, USA Division of Vertebrate Zoology, American Museum of Natural History, New York, NY 10024, USA ARTICLE I NFO ABSTRACT Keywords: MC5R is one of five melanocortin receptor genes found in placental mammals. MC5R plays an important role in Cetacea energy homeostasis and is also expressed in the terminal differentiation of sebaceous glands. Among placental Mammuthus mammals there are multiple lineages that either lack or have degenerative sebaceous glands including Cetacea MC5R (whales, dolphins, and porpoises), Hippopotamidae (hippopotamuses), Sirenia (manatees and dugongs), Pseudogenes Proboscidea (elephants), Rhinocerotidae (rhinos), and Heterocephalus glaber (naked mole rat). Given the loss or Sebaceous glands diminution of sebaceous glands in these taxa, we procured MC5R sequences from publicly available genomes and transcriptomes, supplemented by a newly generated sequence for Choeropsis liberiensis (pygmy hippopotamus), to determine if this gene remains intact or is inactivated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Phylogenetics and Evolution Elsevier

Evolution of the MC5R gene in placental mammals with evidence for its inactivation in multiple lineages that lack sebaceous glands

Loading next page...
 
/lp/elsevier/evolution-of-the-mc5r-gene-in-placental-mammals-with-evidence-for-its-NAz6hDW1Cx
Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
1055-7903
eISSN
1095-9513
D.O.I.
10.1016/j.ympev.2017.12.010
Publisher site
See Article on Publisher Site

Abstract

Molecular Phylogenetics and Evolution 120 (2018) 364–374 Contents lists available at ScienceDirect Molecular Phylogenetics and Evolution journal homepage: www.elsevier.com/locate/ympev Editor’s Choice Article Evolution of the MC5R gene in placental mammals with evidence for its inactivation in multiple lineages that lack sebaceous glands a, b Mark S. Springer , John Gatesy Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, CA 92521, USA Division of Vertebrate Zoology, American Museum of Natural History, New York, NY 10024, USA ARTICLE I NFO ABSTRACT Keywords: MC5R is one of five melanocortin receptor genes found in placental mammals. MC5R plays an important role in Cetacea energy homeostasis and is also expressed in the terminal differentiation of sebaceous glands. Among placental Mammuthus mammals there are multiple lineages that either lack or have degenerative sebaceous glands including Cetacea MC5R (whales, dolphins, and porpoises), Hippopotamidae (hippopotamuses), Sirenia (manatees and dugongs), Pseudogenes Proboscidea (elephants), Rhinocerotidae (rhinos), and Heterocephalus glaber (naked mole rat). Given the loss or Sebaceous glands diminution of sebaceous glands in these taxa, we procured MC5R sequences from publicly available genomes and transcriptomes, supplemented by a newly generated sequence for Choeropsis liberiensis (pygmy hippopotamus), to determine if this gene remains intact or is inactivated

Journal

Molecular Phylogenetics and EvolutionElsevier

Published: Mar 1, 2018

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off