Available online at www.sciencedirect.com ScienceDirect Philip Yuk Kwong Yung and Simon J Elsasser The central dogma of gene expression entails the ﬂow of of the machinery that governs gene expression. At the genetic information from DNA to RNA, then to protein. Decades core of epigenetic regulation are the factors and processes of studies on epigenetics have characterized an additional layer that regulate inheritance of and access to the information of information, where epigenetic states help to shape encoded in the DNA molecules itself, the so-called differential utilization of genetic information. Orchestrating chromatin in eukaryotic cells. conditional gene expressions to elicit a deﬁned phenotype and function, epigenetics states distinguish different cell types or Chromatin at the root of eukaryotic evolution maintain a long-lived memory of past signals. Packaging the The vastly increased genetic content and complexity of genetic information in the nucleus of the eukaryotic cell, the eukaryotic, and in particular metazoan, cells requires a chromatin provides a large regulatory repertoire that highly efﬁcient mechanism to package the DNA mole- capacitates the genome to give rise to many distinct cules into the conﬁned space of the nucleus. Histone epigenomes. We will discuss how reversible, heritable proteins package the DNA molecules
Current Opinion in Chemical Biology – Elsevier
Published: Dec 1, 2017
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