Available online at www.sciencedirect.com ScienceDirect Philip Yuk Kwong Yung and Simon J Elsasser The central dogma of gene expression entails the ﬂow of of the machinery that governs gene expression. At the genetic information from DNA to RNA, then to protein. Decades core of epigenetic regulation are the factors and processes of studies on epigenetics have characterized an additional layer that regulate inheritance of and access to the information of information, where epigenetic states help to shape encoded in the DNA molecules itself, the so-called differential utilization of genetic information. Orchestrating chromatin in eukaryotic cells. conditional gene expressions to elicit a deﬁned phenotype and function, epigenetics states distinguish different cell types or Chromatin at the root of eukaryotic evolution maintain a long-lived memory of past signals. Packaging the The vastly increased genetic content and complexity of genetic information in the nucleus of the eukaryotic cell, the eukaryotic, and in particular metazoan, cells requires a chromatin provides a large regulatory repertoire that highly efﬁcient mechanism to package the DNA mole- capacitates the genome to give rise to many distinct cules into the conﬁned space of the nucleus. Histone epigenomes. We will discuss how reversible, heritable proteins package the DNA molecules
Current Opinion in Chemical Biology – Elsevier
Published: Dec 1, 2017
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera