•Anorexia nervosa is a psychiatric disorder with a typically chronic course.•The new activity-based anorexia rat modelis characterised by a fixed feeding regime and chronic low weight holding phase.•This model enables the study of chronic starvation with initial hyperactivity and ensuring complete amenorrhoea.•A 25% starvation level, early adolescent age and three weeks of starvation were demonstrated to be the best parameters.
Journal of Neuroscience Methods – Elsevier
Published: Jan 1, 2018
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