Objective There is experimental evidence that oxygen-derived free radicals (Superoxide (O 2 − )) play a key role in tissue damage in ischemia-reperfusion injury. Among various antioxidants tested in vitro, natural polyphenols like Epigallocatechine gallate (EGCG) show a 164-fold higher scavenging activity for O 2 − than ascorbic acid We therefore conducted an animal study in order to investigate the impact of EGCG on O 2 − production during reperfusion after defined periods of ischemia in the muscle tissue of the rat, using a recently developed cytochrome c–based biosensor for on-line in vivo monitoring of O 2 − .
Transplantation Proceedings – Elsevier
Published: Dec 1, 2003
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