Epigallocatechin gallate can significantly decrease free oxygen radicals in the reperfusion injury in vivo

Epigallocatechin gallate can significantly decrease free oxygen radicals in the reperfusion... Objective There is experimental evidence that oxygen-derived free radicals (Superoxide (O 2 − )) play a key role in tissue damage in ischemia-reperfusion injury. Among various antioxidants tested in vitro, natural polyphenols like Epigallocatechine gallate (EGCG) show a 164-fold higher scavenging activity for O 2 − than ascorbic acid We therefore conducted an animal study in order to investigate the impact of EGCG on O 2 − production during reperfusion after defined periods of ischemia in the muscle tissue of the rat, using a recently developed cytochrome c–based biosensor for on-line in vivo monitoring of O 2 − . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transplantation Proceedings Elsevier

Epigallocatechin gallate can significantly decrease free oxygen radicals in the reperfusion injury in vivo

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Publisher
Elsevier
Copyright
Copyright © 2003 Elsevier Science Inc.
ISSN
0041-1345
D.O.I.
10.1016/j.transproceed.2003.10.055
Publisher site
See Article on Publisher Site

Abstract

Objective There is experimental evidence that oxygen-derived free radicals (Superoxide (O 2 − )) play a key role in tissue damage in ischemia-reperfusion injury. Among various antioxidants tested in vitro, natural polyphenols like Epigallocatechine gallate (EGCG) show a 164-fold higher scavenging activity for O 2 − than ascorbic acid We therefore conducted an animal study in order to investigate the impact of EGCG on O 2 − production during reperfusion after defined periods of ischemia in the muscle tissue of the rat, using a recently developed cytochrome c–based biosensor for on-line in vivo monitoring of O 2 − .

Journal

Transplantation ProceedingsElsevier

Published: Dec 1, 2003

References

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