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alterations due to tobacco exposure . To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCLCs and their matched normal tissue samples. We identified both common and unique mutation ...
in the frequency of EGFR mutation, KRAS mutation or ALK translocation between patients < 45 years and patients ≥ 45 years. 92.9% of patients < 45 years in our study had potentially targetable genetic alterations ...
that contribute to disparities in lung cancer incidence Smoking Smoking is the strongest risk factor for lung cancer development. Heterogeneity in tobacco exposure across populations is a plausible root ...
with clinicopathological aggressiveness and poorer prognosis (15,16). On the other hand, various genomic alterations , such as mutations of the EGFR , KRAS, BRAF and HER2 genes and fusions involving the ALK , RET and ROS1 ...
, pharmaceutical therapy, tobacco smoking history, and canonical mutations in KRAS/ EGFR / ALK were collected. The age of the patients at diagnosis ranged from 33 to 88 years. The pathological stage, reflecting ...
expression ≥1% and without sensitizing EGFR or ALK alterations , but not only limited to high PD‐L1‐expressing population (PD‐L1 ≥50%) [17]. Compared with standard first‐line chemotherapy, pembrolizumab ...
), had smoked ...
biomarkers in patients newly diagnosed with non-small cell lung cancer: epidermal growth factor receptor ( EGFR ) and anaplastic lymphoma kinase ( ALK ) for treatment guidance.20 The current clinical approach ...
. In addition, environmental tobacco exposure , indoor and outdoor pollution, various carcinogens and genetic susceptibility have all been suggested as etiological factors for LC tumorigenesis in never-smokers ...
of origin to form LUAD. A number of somatic genetic alterations such as KRAS, EGFR , NF1, and BRAF mutations, gene fusions involving ALK , EML4, and ROS1, and copy number variations of the KRAS and EGFR genes ...
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