Environmental chemicals as thyroid hormone analogues: New studies indicate that thyroid hormone receptors are targets of industrial chemicals?

Environmental chemicals as thyroid hormone analogues: New studies indicate that thyroid hormone... Thyroid hormone (TH) is essential for normal brain development, but the specific actions of TH differ across developmental time and brain region. These actions of TH are mediated largely by a combination of thyroid hormone receptor (TR) isoforms that exhibit specific temporal and spatial patterns of expression during animal and human brain development. In addition, TR action is influenced by different co-factors, proteins that directly link the TR protein to functional changes in gene expression. Several recent studies now show that TRs may be unintended targets of chemicals manufactured for industrial purposes, and to which humans and wildlife are routinely exposed. Polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and bisphenol-A (BPA), and specific halogenated derivatives and metabolites of these compounds, have been shown to bind to TRs and perhaps have selective effects on TR functions. A number of common chemicals including polybrominated biphenyls (PBBs) and phthalates may also exert such effects. Considering the importance of TH in brain development, it will be important to pursue the possibilities that these chemicals – or interactions among chemical classes – are affecting children's health by influencing TH signaling in the developing brain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular and Cellular Endocrinology Elsevier

Environmental chemicals as thyroid hormone analogues: New studies indicate that thyroid hormone receptors are targets of industrial chemicals?

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Abstract

Thyroid hormone (TH) is essential for normal brain development, but the specific actions of TH differ across developmental time and brain region. These actions of TH are mediated largely by a combination of thyroid hormone receptor (TR) isoforms that exhibit specific temporal and spatial patterns of expression during animal and human brain development. In addition, TR action is influenced by different co-factors, proteins that directly link the TR protein to functional changes in gene expression. Several recent studies now show that TRs may be unintended targets of chemicals manufactured for industrial purposes, and to which humans and wildlife are routinely exposed. Polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and bisphenol-A (BPA), and specific halogenated derivatives and metabolites of these compounds, have been shown to bind to TRs and perhaps have selective effects on TR functions. A number of common chemicals including polybrominated biphenyls (PBBs) and phthalates may also exert such effects. Considering the importance of TH in brain development, it will be important to pursue the possibilities that these chemicals – or interactions among chemical classes – are affecting children's health by influencing TH signaling in the developing brain.

Journal

Molecular and Cellular EndocrinologyElsevier

Published: Oct 20, 2005

References

  • Developmental disruption of thyroid hormone: correlations with hearing dysfunction in rats
    Crofton, K.M.
  • Thyroid hormones and brain development
    Dussault, J.H.; Ruel, J.
  • Evaluation of chemicals with endocrine modulating activity in yeast-based steroid hormone receptor gene transcription assay
    Gaido, K.W.; Leonard, L.S.; Lovell, S.; Gould, J.C.; Babai, D.; Portier, C.J.; Mcdonell, D.P.
  • Developmental exposure to polychlorinated biphenyls (Aroclor 1254) reduces circulating thyroid hormone concentrations and causes hearing deficits in rats
    Goldey, E.S.; Kehn, L.S.; Lau, C.; Rehnberg, G.L.; Crofton, K.M.
  • Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins
    Huisman, M.; Koopman-Esseboom, C.; Lanting, C.I.; van der Paauw, C.G.; Tuinstra, L.G.; Fidler, V.; Weisglas-Kuperus, N.; Sauer, P.J.; Boersma, E.R.; Touwen, B.C.
  • Polychlorinated biphenyls suppress thyroid hormone-induced transactivation
    Iwasaki, T.; Miyazaki, W.; Takeshita, A.; Kuroda, Y.; Koibuchi, N.
  • Thyroid hormonal activity of the flame retardants tetrabromobisphenol A and tetrachlorobisphenol A
    Kitamura, S.; Jinno, N.; Ohta, S.; Kuroki, H.; Fujimoto, N.
  • Impact of thyroid hormone deficiency on the developing CNS: cerebellar glial and neuronal protein expression in rat neonates exposed to antithyroid drug propylthiouracil
    Li, G.H.; Post, J.; Koibuchi, N.; Sajdel-Sulkowska, E.M.
  • Perinatal exposure to polychlorinated biphenyls differentially affects cerebellar development and motor functions in male and female rat neonates
    Nguon, K.; Baxter, M.G.; Sajdel-Sulkowska, E.M.
  • Molecular mechanisms underlying cell fate specification in the developing telencephalon
    Schuurmans, C.; Guillemot, F.
  • Body mass index and hypothalamic morphology on MRI in children with congenital midline cerebral abnormalities
    Traggiai, C.; Stanhope, R.
  • Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors
    Wu, Y.; Liu, Y.; Levine, E.M.; Rao, M.S.

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