THE JOURNAL OF PEDIATRICS � www.jpeds.com CURRENT BEST EVIDENCE Translating Best Evidence Into Best Care EDITOR’S NOTE: Studies for this column are identiﬁed using the Clinical Queries feature of PubMed, “hand” searching JAMA, JAMA Pediatrics, Pediatrics, The Journal of Pediatrics, and The New England Journal of Medicine, and from customized EvidenceUpdates alerts. EBM PEARL: SYSTEMATIC REVIEW (SR), PART 1: An SR is a methodologically-rigorous overview of the medical literature designed to answer a speciﬁc clinical question. SRs typically attempt to answer therapeutic questions. However, diagnostic test questions and other study designs may also be the basis for an SR. In the hierarchy of the EBM pyramid, the clinical utility of an SR stands above the clinical utility of individual studies, especially if the SR is based on methodologically high-quality studies (eg, randomized, controlled trials). A key distinguishing feature of an SR compared with a standard, or traditional, review, is that an SR has a methods section. Both types of reviews have their place in informing clinical practice. However, it is likely a safer bet to base a clinical decision on the results of an SR. The basic methodologic validity issues of an SR may be minimally assessed through 3
The Journal of Pediatrics – Elsevier
Published: Mar 1, 2018
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