Available online at www.sciencedirect.com ScienceDirect Engineering human cells and tissues through pluripotent stem cells 1 1,2,3 Jeffrey R Jones and Su-Chun Zhang The utility of human pluripotent stem cells (hPSCs) depends on ability to guide hPSCs to functional cells and tissues of their ability to produce functional cells and tissues of the body. the human body. Two parallel methods have been devel- Two strategies have been developed: directed differentiation of oped: directed differentiation to enriched populations of enriched populations of cells that match a regional and functional cells that match a regional and functional identity of those proﬁle and spontaneous generation of three-dimensional normally residing in the human body and spontaneous organoids that resemble tissues in the body. Genomic editing of generation of three-dimensional tissues, called organoids hPSCs and their differentiated cells broadens the use of the that resemble embryonic tissues. Application of genomic hPSC paradigm in studying human cellular function and disease editing in hPSCs and their differentiated cells further as well as developing therapeutics. enables the use of hPSCs in studying early human devel- opment, modeling diseases, and developing therapeutics. Addresses Waisman Center, University of Wisconsin, Madison, WI 53705, United States Speciﬁcation of embryonic germ layers from
Current Opinion in Biotechnology – Elsevier
Published: Aug 1, 2016
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