Engineering approaches to study fibrosis in 3-D in vitro systems

Engineering approaches to study fibrosis in 3-D in vitro systems Available online at www.sciencedirect.com ScienceDirect Engineering approaches to study fibrosis in 3-D in vitro systems 1 1 Ana M Porras , Heather N Hutson , Anthony J Berger and Kristyn S Masters Fibrotic diseases occur in virtually every tissue of the body and myofibroblasts leads to tissue stiffening, which then acts are a major cause of mortality, yet they remain largely in a positive feedback loop to sustain pathological levels untreatable and poorly understood on a mechanistic level. The of myofibroblast activity [5]. Although ECM upregulation development of anti-fibrotic agents has been hampered, in and scar formation can be normal components of tissue part, by the insufficient fibrosis biomimicry provided by repair, these events are dysregulated in fibrosis, where the traditional in vitro platforms. This review focuses on recent heavily crosslinked, collagen-rich matrix progressively advancements toward creating 3-D platforms that mimic key supplants the original functional tissue, eventually lead- features of fibrosis, as well as the application of novel imaging ing to organ dysfunction and failure. and sensor techniques to analyze dynamic extracellular matrix remodeling. Several opportunities are highlighted to apply new Despite the prevalence of fibrotic diseases and the wide tools from the fields of biomaterials, imaging, and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Biotechnology Elsevier

Engineering approaches to study fibrosis in 3-D in vitro systems

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Publisher
Elsevier
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0958-1669
D.O.I.
10.1016/j.copbio.2016.02.006
Publisher site
See Article on Publisher Site

Abstract

Available online at www.sciencedirect.com ScienceDirect Engineering approaches to study fibrosis in 3-D in vitro systems 1 1 Ana M Porras , Heather N Hutson , Anthony J Berger and Kristyn S Masters Fibrotic diseases occur in virtually every tissue of the body and myofibroblasts leads to tissue stiffening, which then acts are a major cause of mortality, yet they remain largely in a positive feedback loop to sustain pathological levels untreatable and poorly understood on a mechanistic level. The of myofibroblast activity [5]. Although ECM upregulation development of anti-fibrotic agents has been hampered, in and scar formation can be normal components of tissue part, by the insufficient fibrosis biomimicry provided by repair, these events are dysregulated in fibrosis, where the traditional in vitro platforms. This review focuses on recent heavily crosslinked, collagen-rich matrix progressively advancements toward creating 3-D platforms that mimic key supplants the original functional tissue, eventually lead- features of fibrosis, as well as the application of novel imaging ing to organ dysfunction and failure. and sensor techniques to analyze dynamic extracellular matrix remodeling. Several opportunities are highlighted to apply new Despite the prevalence of fibrotic diseases and the wide tools from the fields of biomaterials, imaging, and

Journal

Current Opinion in BiotechnologyElsevier

Published: Aug 1, 2016

References

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