Enantioseparation of methamphetamine by supercritical fluid chromatography with cellulose-based packed column

Enantioseparation of methamphetamine by supercritical fluid chromatography with cellulose-based... Forensic Science International 273 (2017) 39–44 Contents lists available at ScienceDirect Forensic Science International journal homepage: www.elsevier.com/locat e/f orsciint Enantioseparation of methamphetamine by supercritical fluid chromatography with cellulose-based packed column Hiroki Segawa*, Yuko T. Iwata, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue National Research Institute of Police Science, 6-3-1, Kashiwanoha, Kashiwa, Chiba 277-0882, Japan A R T I C L E I N F O A B S T R A C T Article history: The enantiomers of methamphetamine were differentiated by supercritical fluid chromatography (SFC) Received 28 November 2016 Received in revised form 27 January 2017 with an enantioselective cellulose-based packed column. The optimization of the chromatographic Accepted 28 January 2017 conditions was achieved by changing column temperature, co-solvent proportion, additive concentra- Available online 4 February 2017 tion, flow rate and back pressure. In particular, the additive concentration crucially changed the resolution between the enantiomers. After determining the optimized conditions, the enantiomers of Keywords: methamphetamine were successfully separated. The analytical precision, accuracy and limit of detection Supercritical fluid chromatography were checked by using the authentic standard and seized real samples. We believe that chiral SFC is a Enantiomer promising method for enantioseparation of forensic samples. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Forensic Science International Elsevier

Enantioseparation of methamphetamine by supercritical fluid chromatography with cellulose-based packed column

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0379-0738
D.O.I.
10.1016/j.forsciint.2017.01.025
Publisher site
See Article on Publisher Site

Abstract

Forensic Science International 273 (2017) 39–44 Contents lists available at ScienceDirect Forensic Science International journal homepage: www.elsevier.com/locat e/f orsciint Enantioseparation of methamphetamine by supercritical fluid chromatography with cellulose-based packed column Hiroki Segawa*, Yuko T. Iwata, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue National Research Institute of Police Science, 6-3-1, Kashiwanoha, Kashiwa, Chiba 277-0882, Japan A R T I C L E I N F O A B S T R A C T Article history: The enantiomers of methamphetamine were differentiated by supercritical fluid chromatography (SFC) Received 28 November 2016 Received in revised form 27 January 2017 with an enantioselective cellulose-based packed column. The optimization of the chromatographic Accepted 28 January 2017 conditions was achieved by changing column temperature, co-solvent proportion, additive concentra- Available online 4 February 2017 tion, flow rate and back pressure. In particular, the additive concentration crucially changed the resolution between the enantiomers. After determining the optimized conditions, the enantiomers of Keywords: methamphetamine were successfully separated. The analytical precision, accuracy and limit of detection Supercritical fluid chromatography were checked by using the authentic standard and seized real samples. We believe that chiral SFC is a Enantiomer promising method for enantioseparation of forensic samples.

Journal

Forensic Science InternationalElsevier

Published: Apr 1, 2017

References

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