Forensic Science International 273 (2017) 39–44 Contents lists available at ScienceDirect Forensic Science International journal homepage: www.elsevier.com/locat e/f orsciint Enantioseparation of methamphetamine by supercritical ﬂuid chromatography with cellulose-based packed column Hiroki Segawa*, Yuko T. Iwata, Tadashi Yamamuro, Kenji Kuwayama, Kenji Tsujikawa, Tatsuyuki Kanamori, Hiroyuki Inoue National Research Institute of Police Science, 6-3-1, Kashiwanoha, Kashiwa, Chiba 277-0882, Japan A R T I C L E I N F O A B S T R A C T Article history: The enantiomers of methamphetamine were differentiated by supercritical ﬂuid chromatography (SFC) Received 28 November 2016 Received in revised form 27 January 2017 with an enantioselective cellulose-based packed column. The optimization of the chromatographic Accepted 28 January 2017 conditions was achieved by changing column temperature, co-solvent proportion, additive concentra- Available online 4 February 2017 tion, ﬂow rate and back pressure. In particular, the additive concentration crucially changed the resolution between the enantiomers. After determining the optimized conditions, the enantiomers of Keywords: methamphetamine were successfully separated. The analytical precision, accuracy and limit of detection Supercritical ﬂuid chromatography were checked by using the authentic standard and seized real samples. We believe that chiral SFC is a Enantiomer promising method for enantioseparation of forensic samples.
Forensic Science International – Elsevier
Published: Apr 1, 2017
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